Fig 1: Production of iBALT-inducing chemokines and expression of cytokines in the lung tissue of immunized mice. BALB/c mice were immunized as described in Figure 4 with or without high (150 µg) DEPs doses. Control mice were immunized in the absence of DEPs. The production of CXCL13 (A), the expression of the iBALT-promoting cytokines Tnfa (B) and Ifna1 (C), type-2 immune responses promoting the cytokines Il4 (D) and Il13 (E), and type-1 immune responses promoting cytokine Ifng (F) were measured in the lung tissue. Black bars indicate significant (*—p < 0.05; **—p < 0.01) differences between the mice immunized without OVA with different DEPs and the respective control without DEPs; green bars indicate significant differences between the mice immunized with a low OVA dose with or without DEPs and the respective control groups; red bars indicate significant differences between mice immunized with a high OVA dose with or without DEPs and respective control groups. The experiment was performed three times. The graphs show the data from three representative experiments (total number of mice included in analysis from all experiments n = 6 per group). The data indicate biological replicates obtained from individual mice.
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