Fig 1: The effect of pretreatment with ENT (30 mg/kg; p.o.) for 6 days, and VAL (15 mg/kg; p.o.) for 6 days, in CP-treated rats (200 mg/kg; i.p.) single dose on day 5, on the antioxidant Nrf-2, NF?B genes expression (A) and proteins concentrations (B) HO-1 and NQO1 proteins levels (C). ENT (sacubitril/valsartan), CP (cyclophosphamide), VAL (valsartan). Data are expressed as mean ± SD (n = 6). Multiple comparisons were performed using one-way ANOVA followed by Tukey’s as post hoc test; *P < 0.05, versus the control group; #P < 0.05, versus the CP-treated group.