Description
A terpene alkaloid; active against a variety of bacteria and C. albicans (MICs = 0.6-10 µg/ml); scavenges DPPH and ABTS radicals in cell-free assays; increases LC3-II and catalase levels and reduces ROS production in normal WI38 lung fibroblasts and H1299, but not A549 or H460, lung cancer cells at 200 µM; a TRPV1 agonist; inhibits TPA-induced NETosis in isolated human neutrophils; induces cortical and systemic hypothermia and reduces infarct volume in a rat model of ischemia-reperfusion injury induced by MCAO at 0.5 mg/kg