U-18666A from Cayman Chemical

Product Specs
ItemU-18666A
CompanyCayman Chemical
Price Pricing Info Supplier Page View Company Product Page
Catalog Number10009085
Quantity10 mg
Research AreaCardiovascular System, Lipid Biochemistry, Lipid Transport, Lipids & Lipoproteins, Neuroscience, Sterol Lipids, Storage & Transport
FormatA crystalline solid
Molecular Weight424.1
Purity≥95%

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) SREBP activation contributes to fatty acid accumulations in necroptosis†RSC Chemical BiologyApril 5, 2023Daniel Lu, Laura R. Parisi, Omer Gokcumen, G. Ekin Atilla-Gokcumen#210-TA/CF). Atorvastatin (Cat # 10493). BIBB 515 (Cat # 10010517), Ro48-8071 (Cat # 10006415), U18666A (Cat # 10009085), Betulin (Cat # 11041), necrosulfonamide (Cat # 20844) and filipin III (Cat # 70440) were obtained

(2) Cholesterol content regulates silica-induced lysosomal membrane permeabilityFrontiers in ToxicologyFebruary 13, 2023Matthew J. Sydor, Rebekah L. Kendall, Andrij Holianmeasurements was Di-4-ANEPPDHQ, which was purchased from ThermoFisher (Waltham, MA). U18666a (Item No. 10009085) was obtained from Cayman Chemical (Ann Arbor, MI). The fluorescent substrate for n-acetyl-β-glucosaminidase

(3) Cellular cholesterol licenses Legionella pneumophila intracellular replication in macrophagesMicrobial CellJanuary 2, 2023Edna Ondari, Ashley Wilkins, Brian Latimer, Ana-Maria Dragoi, Stanimir S. Ivanovdescribed [79]. Reagents The following reagents were purchased from Cayman Chemicals - u18666A (cat #10009085), ketoconazole (cat #15212), Filipin III (cat #70440), NileRed (cat # 30787). Gemcitabine (cat #G6423)

(4) Sterol dysregulation in Smith-Lemli-Opitz syndrome causes astrocyte immune reactivity through microglia crosstalkDisease models & mechanismsDecember 1, 2022Freel BA, Kelvington BA, Sengupta S, Mukherjee M, Francis KR.(5 µM; DHCR7 inhibitor; Cayman Chemical, 14611), U18666A (20 nM; DHCR24 inhibitor; Cayman Chemical, 10009085) and atorvastatin (2.5 µM; HMG-CoA reductase inhibitor; Cayman Chemical, 10493). All comparisons for

(5) Novel Insights Into Sterol Uptake and Intracellular Cholesterol Trafficking During Eimeria bovis Macromeront FormationFrontiers in Cellular and Infection MicrobiologyFebruary 11, 2022Liliana M. R. Silva, Zahady D. Velásquez, Sara López-Osorio, Carlos Hermosilla, Anja TaubertAdditionally, progesterone (25–75 µM; Sigma-Aldrich, P0130) and U18666A (7.5 µM; Cayman Chemical Company, 10009085) were used, which are both known to block intracellular sterol transport and release from endosomes.

(6) Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin-mediated endocytosisCell ReportsNovember 16, 2021Ruthellen H. Anderson, Kem A. Sochacki, Harika Vuppula, Brandon L. Scott, Elizabeth M. Bailey, Maycie M. Schultz, Jason G. Kerkvliet, Justin W. Taraska, Adam D. Hoppe, Kevin R. Francisand recombinant proteins",, AY9944,Cayman Chemical,Item No. 14611 U-18666A,Cayman Chemical,Item No. 10009085 Atorvastatin,Cayman Chemical,Item No. 10493 Simvastatin,Cayman Chemical,Item No. 10010344 methyl-β-cyclodextrin

(7) Iron loading induces cholesterol synthesis and sensitizes endothelial cells to TNFα-mediated apoptosisThe Journal of biological chemistryOctober 1, 2021Fisher AL, Srole DN, Palaskas NJ, Meriwether D, Reddy ST, Ganz T, Nemeth E.for 40 h. For cholesterol-depletion studies, HUVECs were treated with 1 μM U18666A (Cayman Chemicals #10009085), 0.3% HPCD (#H107), or 50 μM MCD for the indicated times. For inflammation studies, HUVECs were treated

(8) Mevalonate Pathway-mediated ER Homeostasis Is Required for Haploid Stability in Human Somatic CellsCell Structure and FunctionFebruary 19, 2021Kan Yaguchi, Kimino Sato, Koya Yoshizawa, Daisuke Mikami, Kohei Yuyama, Yasuyuki Igarashi, Gabor Banhegyi, Eva Margittai, Ryota Ueharacompounds Compounds were purchased from suppliers as follows: Pitavasta‐ tin (163-24861, Wako); U18666A (10009085, Cayman Chemi‐ cal); Cholesterol (SLBZ0657, Sigma-Aldrich); FTI-277 (S7465, Selleck); GGTI-298 (S7466,

(9) Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2Proceedings of the National Academy of SciencesAugust 25, 2020Yuan-Lin Kang et al.gift from N. Gray, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA (33), U-18666A (10009085) and Filipin III (70440) were from Cayman Chemical, Bafilomycin A1 (B1793-2UG) was from Sigma-Aldrich,

(10) Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseaseseLifeFebruary 18, 2019King Faisal Yambire, Lorena Fernandez-Mosquera, Robert Steinfeld, Christiane Mühle, Elina Ikonen, Ira Milosevic, Nuno Raimundo(Biotrend, BG0162), 5 µM Sew2871 (Cayman, 10006440), 20 µM U0126 (Millipore, 662005), 10 µM U18666A (Cayman, 10009085), 10 µM W146 (Sigma-Aldrich, W1020), 2 µM FTY720 (Selleckchem, S5002) and 4 µM Staurosporine (Sigma-Aldrich,

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U-18666A from Cayman Chemical

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Cayman Chemical

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U-18666A from Cayman Chemical

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