KT 5720 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemKT 5720
CompanyTocris Bioscience, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog Number1288/100U
Quantity100 ug
Brand/TrademarkTocris, a Bio-Techne Brand
Purity0.97
Molecular Weight537.61
Molecule Name(9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester
FormulaC₃₂H₃₁N₃O₅
StorageStore at -20°C

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Pimavanserin, a 5HT_2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer's diseaseJournal of neurochemistryMarch 1, 2021Yuede CM, Wallace CE, Davis TA, Gardiner WD, Hettinger JC, Edwards HM, Hendrix RD, Doherty BM, Yuede KM, Burstein ES, et al.

(2) Application of Antibodies to Neuronally Expressed Nogo-A Increases Neuronal Survival and Neurite OutgrowthInternational journal of molecular sciencesJuly 30, 2020Nagaraj V, Theis T, Johal AS, Seth A, Gore J, Arsha N, Patel M, Hao HB, Kurian N, Schachner M.12S)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo [1,2,3-fg:30 ,20 ,10 -kl]pyrrolo[3,4-i][1,6]benzo-diazocine-10-carboxylic acid hexyl ester (KT 5720; Cat#1288/100U; CAS 108068-98-0) were from Tocris Bioscience (Bristol, UK). Calcein-AM (Cat#C1430; CAS 148504-34-1)

(3) Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungsAntiviral researchJuly 1, 2020Salinas FM, Nebreda AD, Vázquez L, Gentilini MV, Marini V, Benedetti M, Nabaes Jodar MS, Viegas M, Shayo C, Bueno CA.

(4) The readily-releasable pool dynamically regulates multivesicular releaseeLifeJuly 31, 2019Vaden JH, Banumurthy G, Gusarevich ES, Overstreet-Wadiche L, Wadiche JI.

(5) Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-βEMBO molecular medicineSeptember 1, 2018Xu H, Rajsombath MM, Weikop P, Selkoe DJ.

(6) Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophyThe Journal of biological chemistryJuly 27, 2018Cruz JM, Hupper N, Wilson LS, Concannon JB, Wang Y, Oberhauser B, Patora-Komisarska K, Zhang Y, Glass DJ, Trendelenburg AU, et al.

(7) Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolismNature cell biologyJuly 1, 2018Patra KC, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, Grossman EA, Ji F, Sadreyev RI, Liss AS, et al.

(8) Elevated levels of calcitonin gene-related peptide in upper spinal cord promotes sensitization of primary trigeminal nociceptive neuronsNeuroscienceDecember 17, 2016Cornelison LE, Hawkins JL, Durham PL.

(9) Endocannabinoid dynamics gate spike-timing dependent depression and potentiationeLifeFebruary 27, 2016Cui Y, Prokin I, Xu H, Delord B, Genet S, Venance L, Berry H.

(10) Potentiation of Schaffer-Collateral CA1 Synaptic Transmission by eEF2K and p38 MAPK Mediated MechanismsFrontiers in cellular neuroscienceJanuary 1, 2016Weng W, Chen Y, Wang M, Zhuang Y, Behnisch T.

(11) Progesterone receptor membrane component-1 regulates hepcidin biosynthesisThe Journal of clinical investigationJanuary 1, 2016Li X, Rhee DK, Malhotra R, Mayeur C, Hurst LA, Ager E, Shelton G, Kramer Y, McCulloh D, Keefe D, et al.

(12) Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitinScientific reportsJuly 21, 2015Chang L, Cui W, Yang Y, Xu S, Zhou W, Fu H, Hu S, Mak S, Hu J, Wang Q, et al.

(13) Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cellsBiochimica et biophysica actaJuly 1, 2015Parnell E, Koschinski A, Zaccolo M, Cameron RT, Baillie GS, Baillie GL, Porter A, McElroy SP, Yarwood SJ.

(14) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with IsoproterenolPloS oneJanuary 1, 2015Merino B, Quesada I, Hernández-Cascales J.

(15) Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2BPloS oneJanuary 1, 2015Brignell JL, Perry MD, Nelson CP, Willets JM, Challiss RA, Davies NW.

(16) The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and DifferentiationPloS oneJanuary 1, 2015Smith M, Wilson R, O'Brien S, Tufarelli C, Anderson SI, O'Sullivan SE.

(17) Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditionsInvestigative ophthalmology & visual scienceDecember 18, 2014Thakran S, Zhang Q, Morales-Tirado V, Steinle JJ.

(18) Central vagal afferent endings mediate reduction of food intake by melanocortin-3/4 receptor agonistThe Journal of neuroscience : the official journal of the Society for NeuroscienceSeptember 17, 2014Campos CA, Shiina H, Ritter RC.

(19) Loss of long-term depression in the insular cortex after tail amputation in adult miceMolecular painJanuary 8, 2014Liu MG, Zhuo M.

(20) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMPNatureDecember 6, 2012Lee GS, Subramanian N, Kim AI, Aksentijevich I, Goldbach-Mansky R, Sacks DB, Germain RN, Kastner DL, Chae JJ.

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KT 5720

KT 5720 from Tocris Bioscience, a Bio-Techne Brand

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Tocris Bioscience, a Bio-Techne Brand

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KT 5720 from Tocris Bioscience, a Bio-Techne Brand

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