GANT 61 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemGANT 61
CompanyTocris Bioscience, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog Number3191/10
Quantity10 mg (also 50 mg)
Brand/TrademarkTocris, a Bio-Techne Brand
Purity0.98
Molecular Weight429.61
Molecule Name2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
FormulaC₂₇H₃₅N₅
StorageStore at -20°C

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Non-canonical Hedgehog signaling regulates spinal cord and muscle regeneration in Xenopus laevis larvaeeLifeMay 6, 2021Andrew M Hamilton, Olga A Balashova, Laura N BorodinskyDMSO Chemical compound, drug KT5720 Tocris 1288 10 mM stock in DMSO Chemical compound, drug GANT61 Tocris 3191 10 mM srock in DMSO Chemical compound, drug Tricaine-S Syndel MS 222 Anesthetic Animals X. laevis

(2) Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancereLifeMay 28, 2019Adams CR, Htwe HH, Marsh T, Wang AL, Montoya ML, Subbaraj L, Tward AD, Bardeesy N, Perera RM.at 1 mg/mL and cells assayed 2–3 days later. Drug treatment Cells were treated with 5 mM of GANT61 (3191/10; R and D Systems) for 3–5 days prior to collection of RNA or protein lysates. Alternatively, iKRAS cells

(3) Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61Journal of enzyme inhibition and medicinal chemistryDecember 1, 2018Calcaterra A, Iovine V, Botta B, Quaglio D, D'Acquarica I, Ciogli A, Iazzetti A, Alfonsi R, Lospinoso Severini L, Infante P, et al.

(4) Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cellsCancer lettersDecember 28, 2017Oladapo HO, Tarpley M, Sauer SJ, Addo KA, Ingram SM, Strepay D, Ehe BK, Chdid L, Trinkler M, Roques JR, et al.

(5) Hedgehog signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the chick retinaDevelopment (Cambridge, England)August 1, 2015Todd L, Fischer AJ.

(6) Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic EffectsClinical cancer research : an official journal of the American Association for Cancer ResearchMay 15, 2015Wellbrock J, Latuske E, Köhler J, Wagner K, Stamm H, Vettorazzi E, Vohwinkel G, Klokow M, Uibeleisen R, Ehm P, et al.

(7) Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosisOncotargetJanuary 30, 2015Lim CB, Prêle CM, Baltic S, Arthur PG, Creaney J, Watkins DN, Thompson PJ, Mutsaers SE.

(8) Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cellsCancer researchSeptember 1, 2011Mazumdar T, Devecchio J, Agyeman A, Shi T, Houghton JA.