U0126 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemU0126
CompanyTocris Bioscience, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog Number1144/5
Quantity5 mg (also 25 mg)
Brand/TrademarkTocris, a Bio-Techne Brand
Molecular Weight380.48
Molecule Name1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
FormulaC₁₈H₁₆N₆S₂
StorageDesiccate at +4°C

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Pituitary adenylate cyclase-activating polypeptide attenuates mitochondria-mediated oxidative stress and neuronal apoptosis after subarachnoid hemorrhage in ratsFree Radical Biology and MedicineOctober 1, 2021Yuanjian Fang et al.Tocris Bioscience, Minneapolis, MN), and ERK inhibitor, U0126-EtOH (30mg/kg, dissolved with DMSO, No. 1144/5, Tocris Bioscience, Minneapolis, MN), were administrated 1 h after surgery via i.c.v. injection. The

(2) Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiationCell reportsJuly 20, 2021Li XH, Matsuura T, Xue M, Chen QY, Liu RH, Lu JS, Shi W, Fan K, Zhou Z, Miao Z, et al.

(3) GDNF/RET Signaling Pathway Activation Eliminates Lewy Body Pathology in Midbrain Dopamine NeuronsMovement disorders : official journal of the Movement Disorder SocietyDecember 1, 2020Chmielarz P, Er Ş, Konovalova J, Bandres L, Hlushchuk I, Albert K, Panhelainen A, Luk K, Airavaara M, Domanskyi A.6475), 10 µM LY294002 (PI-3 kinase 22 inhibitor) (Tocris, 1130), 10 µM U0126 (MEK1/2 inhibitor) (Tocris, 1144), 5 µM MK2206 (Akt kinase 17 bioRxiv preprint doi: https://doi.org/10.1101/752899; this version posted

(4) Nanovibrational Stimulation of Mesenchymal Stem Cells Induces Therapeutic Reactive Oxygen Species and Inflammation for Three-Dimensional Bone Tissue EngineeringACS nanoAugust 25, 2020Orapiriyakul W, Tsimbouri MP, Childs P, Campsie P, Wells J, Fernandez-Yague MA, Burgess K, Tanner KE, Tassieri M, Meek D, et al.function,inhibitors,cat no./batch,working concentration ERK inhibitor,"U126, Tocris",1144/5,10 μM P38 inhibitor,"SB 202190, Tocris",1264/5,5 μM JNK inhibitor,"SP600125, Tocris",1496/10,25 μM NFkB

(5) Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11ACS chemical neuroscienceAugust 21, 2019Domin H, Piergies N, Pięta E, Wyska E, Pochwat B, Wlaź P, Śmiałowska M, Paluszkiewicz C, Szewczyk B.

(6) Purpurogallin Protects Keratinocytes from Damage and Apoptosis Induced by Ultraviolet B Radiation and Particulate Matter 2.5Biomolecules & therapeuticsJuly 1, 2019Zhen AX, Piao MJ, Hyun YJ, Kang KA, Ryu YS, Cho SJ, Kang HK, Koh YS, Ahn MJ, Kim TH, et al.

(7) Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseasesGliaJuly 1, 2019Suo N, Guo YE, He B, Gu H, Xie X.

(8) Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 PathwayCellsMay 29, 2019Szybowska P, Kostas M, Wesche J, Wiedlocha A, Haugsten EM.

(9) Neural control of body-plan axis in regenerating planariaPLoS computational biologyApril 1, 2019Pietak A, Bischof J, LaPalme J, Morokuma J, Levin M.

(10) Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural WiringMolecular cellFebruary 7, 2019Cagnetta R, Wong HH, Frese CK, Mallucci GR, Krijgsveld J, Holt CE.

(11) Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1Blood cancer journalJanuary 15, 2019Ernst D, Williams BA, Wang XH, Yoon N, Kim KP, Chiu J, Luo ZJ, Hermans KG, Krueger J, Keating A.

(12) Inhibition of TGF-β1 Signaling by IL-15: A Novel Role for IL-15 in the Control of Renal Epithelial-Mesenchymal Transition: IL-15 Counteracts TGF-β1-Induced EMT in Renal FibrosisInternational journal of cell biologyJanuary 1, 2019Devocelle A, Lecru L, François H, Desterke C, Gallerne C, Eid P, Estelle O, Azzarone B, Giron-Michel J.

(13) Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T CellsCell reportsNovember 20, 2018Kim C, Hu B, Jadhav RR, Jin J, Zhang H, Cavanagh MM, Akondy RS, Ahmed R, Weyand CM, Goronzy JJ.

(14) Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasisJCI insightOctober 18, 2018Andersson P, Yang Y, Hosaka K, Zhang Y, Fischer C, Braun H, Liu S, Yu G, Liu S, Beyaert R, et al.

(15) Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiationAmerican journal of physiology. Lung cellular and molecular physiologyMay 1, 2018Noskovičová N, Heinzelmann K, Burgstaller G, Behr J, Eickelberg O.

(16) The homozygous CX3CR1-M280 mutation impairs human monocyte survivalJCI insightFebruary 8, 2018Collar AL, Swamydas M, O'Hayre M, Sajib MS, Hoffman KW, Singh SP, Mourad A, Johnson MD, Ferre EM, Farber JM, et al.

(17) Integrin CD11b negatively regulates Mincle-induced signaling via the Lyn-SIRPα-SHP1 complexExperimental & molecular medicineFebruary 5, 2018Zhang Q, Lee WB, Kang JS, Kim LK, Kim YJ.

(18) Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer CellsEndocrinologyJanuary 1, 2018Li Z, Levine KM, Bahreini A, Wang P, Chu D, Park BH, Oesterreich S, Lee AV.

(19) Capsaicin-induced TRIB3 upregulation promotes apoptosis in cancer cellsCancer management and researchJanuary 1, 2018Lin RJ, Wu IJ, Hong JY, Liu BH, Liang RY, Yuan TM, Chuang SM.

(20) Epidermal Growth Factor Receptor Signaling Enhances the Proinflammatory Effects of Staphylococcus aureus Gamma-Toxin on the MucosaToxinsJune 28, 2017Gillman AN, Breshears LM, Kistler CK, Finnegan PM, Torres VJ, Schlievert PM, Peterson ML.

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U0126

U0126 from Tocris Bioscience, a Bio-Techne Brand

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Tocris Bioscience, a Bio-Techne Brand

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U0126 from Tocris Bioscience, a Bio-Techne Brand

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