LY 294002 hydrochloride from Tocris Bioscience, a Bio-Techne Brand | Biocompare.com

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LY 294002 hydrochloride

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

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Tocris Bioscience, a Bio-Techne Brand for
LY 294002 hydrochloride

Description

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Product Specs
ItemLY 294002 hydrochloride
CompanyTocris Bioscience, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog Number1130/5
Quantity5 mg (also 25 mg)
Brand/TrademarkTocris, a Bio-Techne Brand
Purity0.99
Molecular Weight343.81
Molecule Name2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
FormulaC₁₉H₁₇NO₃.HCl
StorageStore at RT

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Human vascular cell responses to the circulating bone hormone osteocalcinJournal of cellular physiologyNovember 1, 2019Millar SA, Anderson SI, O'sullivan SE.

(2) Extracorporeal shock waves protect cardiomyocytes from doxorubicin-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axisScientific reportsAugust 21, 2019Yoon Lee J, Chung J, Hwa Kim K, Hyun An S, Yi JE, Ae Kwon K, Kwon K.

(3) Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11ACS chemical neuroscienceAugust 21, 2019Domin H, Piergies N, Pięta E, Wyska E, Pochwat B, Wlaź P, Śmiałowska M, Paluszkiewicz C, Szewczyk B.

(4) The Protective Effect of Insulin on Rat Cortical Neurons in Oxidative Stress and Its Dependence on the Modulation of Akt, GSK-3beta, ERK1/2, and AMPK ActivitiesInternational journal of molecular sciencesJuly 29, 2019Zakharova IO, Sokolova TV, Bayunova LV, Zorina II, Rychkova MP, Shpakov AO, Avrova NF.

(5) The standardized Korean Red Ginseng extract and its ingredient ginsenoside Rg3 inhibit manifestation of breast cancer stem cell-like properties through modulation of self-renewal signalingJournal of ginseng researchJuly 1, 2019Oh J, Yoon HJ, Jang JH, Kim DH, Surh YJ.

(6) Dual RXR motifs regulate nerve growth factor-mediated intracellular retention of the delta opioid receptorMolecular biology of the cellMarch 1, 2019Shiwarski DJ, Crilly SE, Dates A, Puthenveedu MA.

(7) Intracellular emetic signaling evoked by the L-type Ca²⁺ channel agonist FPL64176 in the least shrew (Cryptotis parva)European journal of pharmacologySeptember 5, 2018Zhong W, Chebolu S, Darmani NA.

(8) The homozygous CX3CR1-M280 mutation impairs human monocyte survivalJCI insightFebruary 8, 2018Collar AL, Swamydas M, O'Hayre M, Sajib MS, Hoffman KW, Singh SP, Mourad A, Johnson MD, Ferre EM, Farber JM, et al.

(9) PI3Kδ activates E2F1 synthesis in response to mRNA translation stressNature communicationsDecember 13, 2017Gnanasundram SV, Pyndiah S, Daskalogianni C, Armfield K, Nylander K, Wilson JB, Fåhraeus R.

(10) Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1BMC cancerNovember 29, 2017Ali R, Samman N, Al Zahrani H, Nehdi A, Rahman S, Khan AL, Al Balwi M, Alriyees LA, Alzaid M, Al Askar A, et al.

(11) Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterolScientific reportsSeptember 5, 2017Cameron RB, Beeson CC, Schnellmann RG.

(12) Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by DexamethasoneInternational journal of molecular sciencesAugust 19, 2017Bossmann M, Ackermann BW, Thome UH, Laube M.

(13) A pluripotent stem cell-based model for post-implantation human amniotic sac developmentNature communicationsAugust 8, 2017Shao Y, Taniguchi K, Townshend RF, Miki T, Gumucio DL, Fu J.

(14) Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticityThe Journal of cell biologyAugust 7, 2017Lei W, Myers KR, Rui Y, Hladyshau S, Tsygankov D, Zheng JQ.

(15) PI3K class II α regulates δ-opioid receptor export from the trans-Golgi networkMolecular biology of the cellAugust 1, 2017Shiwarski DJ, Darr M, Telmer CA, Bruchez MP, Puthenveedu MA.

(16) CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K⁺ channelsAmerican journal of physiology. Cell physiologyJuly 1, 2017Jantarajit W, Lertsuwan K, Teerapornpuntakit J, Krishnamra N, Charoenphandhu N.

(17) Negative regulation of ERK1/2 by PI3K is required for the protective effects of Pyropia yezoensis peptide against perfluorooctane sulfonate-induced endoplasmic reticulum stressMolecular medicine reportsMay 1, 2017Oh JH, Kim EY, Choi YH, Nam TJ.

(18) The GABA_B positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cells lacking functional GABA_B receptorsEuropean journal of pharmacologyJanuary 5, 2017Olianas MC, Dedoni S, Onali P.

(19) Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 may protect against cognitive impairment in rats of chronic cerebral hypoperfusion via PI3K/AKT signalingBehavioural brain researchOctober 15, 2016Su SH, Wang YQ, Wu YF, Wang DP, Lin Q, Hai J.

(20) Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cellsOncotargetOctober 11, 2016Torres A, Vargas Y, Uribe D, Jaramillo C, Gleisner A, Salazar-Onfray F, López MN, Melo R, Oyarzún C, San Martín R, et al.

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7/19/2019LY 294002 Inhibits 15d-PGJ2-Induced Akt Phosphorylation Peter Frankl.LY 294002 can be used to investigate PI3K-Akt signaling.
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4/29/2019LY 294002 Blocks LPA-Mediated COX-2 Expression Chintan KoyaniLY 294002 abolished LPA-induced COX-2 expression