CometAssay Lysis Solution (2 x 500 mL) from R&D Systems, a Bio-Techne Brand

Product Specs
ItemCometAssay Lysis Solution (2 x 500 mL)
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog Number4250-050-01
Quantity1 L
SpeciesMulti-Species
Brand/TrademarkR&D Systems, a Bio-Techne Brand
StorageStore the unopened product at room temperature. Do not use past expiration date

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1International Journal of Molecular SciencesNovember 23, 2023Debanu Das, Matthew A. J. Duncton, Taxiarchis M. Georgiadis, Patricia Pellicena, Jennifer Clark, Robert W. Sobol, Millie M. Georgiadis, John King-Underwood, David V. Jobes, Caleb Chang, et al.then submerged in lysis solution with Triton X-100 detergent (BioTechne, Minneapolis, MN, USA, Cat# 4250-050-01) for 2 h at 4 °C and subsequently electrophoresed under alkaline (pH > 13) conditions (200 mM NaOH,

(2) Prolonged particulate hexavalent chromium exposure induces RAD51 foci inhibition and cytoplasmic accumulation in immortalized and primary human lung bronchial epithelial cellsToxicology and applied pharmacologyNovember 15, 2023Meaza I, Williams AR, Lu H, Kouokam JC, Toyoda JH, Croom-Perez TJ, Wise SS, Aboueissa AE, Wise JP Sr.

(3) Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adultsDNA repairSeptember 1, 2023Smith JT, Noren Hooten N, Mode NA, Zonderman AB, Ezike N, Kaushal S, Evans MK.

(4) Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium bindingThe Journal of biological chemistryAugust 1, 2023Shimizu N, Hamada Y, Morozumi R, Yamamoto J, Iwai S, Sugiyama KI, Ide H, Tsuda M.and maintained at 4 °C for 10 min. The slides were immersed in prechilled CometAssay Lysis Solution (4250-050-01, R&D Systems) overnight, after which they were incubated for 15 min in prechilled neutral electrophoresis buffer

(5) PCNA Ser46-Leu47 residues are crucial in preserving genomic integrityPloS oneJanuary 1, 2023Kim S, Kim Y, Kim Y, Yoon S, Lee KY, Lee Y, Kang S, Myung K, Oh CK.

(6) Cellular photo(geno)toxicity of gefitinib after biotransformationFrontiers in pharmacologyJanuary 1, 2023El Ouardi M, Tamarit L, Vayá I, Miranda MA, Andreu I.

(7) NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitorsScience advancesDecember 9, 2022Meroni A, Grosser J, Agashe S, Ramakrishnan N, Jackson J, Verma P, Baranello L, Vindigni A.

(8) Inhibition of GABAA receptors in intestinal stem cells prevents chemoradiotherapy-induced intestinal toxicityJournal of Experimental MedicineDecember 5, 2022Cuiyu Zhang, Yuping Zhou, Junjie Zheng, Nannan Ning, Haining Liu, Wenyang Jiang, Xin Yu, Kun Mu, Yan Li, Wei Guo, et al.indicated treatments and suspended in low melting agarose. After lysis in the Comet Assay Lysis Solution (4250-050-01; R&D System) for 2 h, the mixture was separated by electrophoresis under alkaline conditions at 17 V

(9) The N(6)-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrityNature communicationsOctober 28, 2022Yoshinaga M, Han K, Morgens DW, Horii T, Kobayashi R, Tsuruyama T, Hia F, Yasukura S, Kajiya A, Cai T, et al.

(10) Overcoming Temozolomide Resistance in Glioblastoma via Enhanced NAD(+) Bioavailability and Inhibition of Poly-ADP-Ribose GlycohydrolaseCancersJuly 22, 2022Li J, Koczor CA, Saville KM, Hayat F, Beiser A, McClellan S, Migaud ME, Sobol RW.

(11) Cellular mechanism of action of 2-nitroimidazoles as hypoxia-selective therapeutic agentsRedox biologyJune 1, 2022Rashed FB, Diaz-Dussan D, Mashayekhi F, Macdonald D, Nation PN, Yang XH, Sokhi S, Stoica AC, El-Saidi H, Ricardo C, et al.point agarose, and spread on comet slides. After the gel solidified, slides were put in lysis solution (4250-050-01, R&D Systems, Minneapolis, MN) for 1 h, and then in unwinding solution (200 mM NaOH, 2.5 mM EDTA) for

(12) Oxidative Stress and Deregulated DNA Damage Response Network in Lung Cancer PatientsBiomedicinesMay 26, 2022Stefanou DT, Kouvela M, Stellas D, Voutetakis K, Papadodima O, Syrigos K, Souliotis VL.

(13) Mutations of the DNA repair gene PNKP in a patient with microcephaly, seizures, and developmental delay (MCSZ) presenting with a high-grade brain tumorScientific reportsMarch 30, 2022Jiang B, Murray C, Cole BL, Glover JNM, Chan GK, Deschenes J, Mani RS, Subedi S, Nerva JD, Wang AC, et al.

(14) Evaluation of phototoxicity induced by the anticancer drug rucaparibScientific reportsMarch 2, 2022Mateos-Pujante A, Jiménez MC, Andreu I.

(15) Combination treatment of arsenic trioxide and osimertinib in recurrent and metastatic head and neck squamous cell carcinomaAmerican journal of cancer researchJanuary 1, 2022Hsieh CY, Chang WC, Lin CC, Chen JH, Lin CY, Liu CH, Lin C, Hung MC.

(16) Performance Evaluation for Repair of HSGc-C5 Carcinoma Cell Using Geant4-DNACancersNovember 30, 2021Sakata D, Suzuki M, Hirayama R, Abe Y, Muramatsu M, Sato S, Belov O, Kyriakou I, Emfietzoglou D, Guatelli S, et al.

(17) Genetic vulnerabilities upon inhibition of DNA damage responseNucleic acids researchAugust 20, 2021Wang C, Tang M, Chen Z, Nie L, Li S, Xiong Y, Szymonowicz KA, Park JM, Zhang H, Feng X, et al.

(18) Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damageNature communicationsJuly 16, 2021Wu X, Wang B.

(19) DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylationNature communicationsMay 3, 2021Ren W, Fan H, Grimm SA, Kim JJ, Li L, Guo Y, Petell CJ, Tan XF, Zhang ZM, Coan JP, et al.

(20) Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitorsTheranosticsJanuary 1, 2021Grimley E, Cole AJ, Luong TT, McGonigal SC, Sinno S, Yang D, Bernstein KA, Buckanovich RJ.

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CometAssay Lysis Solution (2 x 500 mL) from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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CometAssay Lysis Solution (2 x 500 mL) from R&D Systems, a Bio-Techne Brand

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