GM 6001, MMP inhibitor from Abcam

Product Specs
ItemGM 6001, MMP inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120845
Quantity1 MG, 5 MG
Purity0.99
Typeinhibitor

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Syndecan-1 shedding destroys epithelial adherens junctions through STAT3 after renal ischemia/reperfusion injuryiScienceNovember 17, 2023Man Guo, Daoqi Shen, Yiqi Su, Jiarui Xu, Shuan Zhao, Weidong Zhang, Yaqiong Wang, Wuhua Jiang, Jialin Wang, Xuemei Geng, et al.proteins","Chemicals, peptides, and recombinant proteins" ,, Matrigel matrix,Corning,Cat#:354277 GM6001,Abcam,Cat#: ab120845 S3I-201,Selleck,Cat#: S1155 AG490,Selleck,Cat#: S1143 Trizol,Invitrogen,Cat#: 15596018 ,, Critical

(2) How the mechanobiology orchestrates the iterative and reciprocal ECM-cell cross-talk that drives microtissue growthScience advancesMarch 29, 2023Benn MC, Pot SA, Moeller J, Yamashita T, Fonta CM, Orend G, Kollmannsberger P, Vogel V.lapatinib (1 μM; GW572016, Axon Medchem, USA), inhibition of broad-spectrum MMP with GM6001 (25 μM; ab120845, Abcam, UK), inhibition of MMP-2/-9 with SB-3CT (5 μM; ab141579, Abcam, UK), inhibition of α2β1-integrin

(3) Click chemistry functionalization of self‐assembling peptide hydrogelsJournal of Biomedical Materials Research Part AMarch 1, 2023Joe T. Sharick, Angelina J. Atieh, Keith J. Gooch, Jennifer L. LeightLAP for 1 h prior to any UV exposure. To explore the role of MMPs, in some cultures, GM6001 (Abcam #ab120845) was supplemented in cell culture media for a final concentration of 10 μM. Encapsulated cells were

(4) Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8+/− mouse model of ASD-like behaviorNature CommunicationsDecember 1, 2022You Yu, Bing Zhang, Peifeng Ji, Zhenqiang Zuo, Yongxi Huang, Ning Wang, Chang Liu, Shuang-Jiang Liu, Fangqing Zhaomice aged 4–5 weeks; 0.2 ml for mice older than 5 weeks). GM6001 administration GM6001 (Abcam, Cat # ab120845) was dissolved in DMSO (10 mg/ml) as the stock solution and stored at −80 °C until use. Before administrating

(5) Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formationScience advancesNovember 19, 2021Oda Y, Takahashi C, Harada S, Nakamura S, Sun D, Kiso K, Urata Y, Miyachi H, Fujiyoshi Y, Honigmann A, et al.incubated with the indicated MMP at 37°C for 24 hours. For MMP inhibition, MMP inhibitor GM6001 (50 μM; ab120845, Abcam) was added to the colon culture. Measurement of protease activity Protease activity was measured

(6) The biomechanical basis of biased epithelial tube elongation in lung and kidney developmentDevelopmentMay 1, 2021Lisa Conrad, Steve Vincent Maurice Runser, Harold Fernando Gómez, Christine Michaela Lang, Mathilde Sabine Dumond, Aleksandra Sapala, Laura Schaumann, Odyssé Michos, Roman Vetter, Dagmar IberMMP inhibitor lung cultures, the culture medium was supplemented with 2.5 µM or 20 µM GM6001 (Abcam; ab120845; APN17122-1-1) before live imaging. To investigate the developmental dynamics of isolated lung bud and

(7) Membrane particles from mesenchymal stromal cells reduce the expression of fibrotic markers on pulmonary cellsPLOS ONEMarch 17, 2021Ana Merino, Martin J. Hoogduijn, Maria Molina-Molina, Elena G. Arias-Salgado, Sander S. Korevaar, Carla C. Baan, Ana Montes-WorboysAPMA activation, and MP incubated with 10 μM of GM6001 (a pan-matrix metalloproteinase inhibitor) (ab120845; Abcam) after 3h with APMA were used as controls of the technique. The assay is based on a fluorescence resonance energy transfer (FRET

(8) Physical and functional cell-matrix uncoupling in a developing tissue under tensionDevelopmentJune 1, 2019Amsha Proag, Bruno Monier, Magali Suzanne5B, Movie 6), leg discs were mounted in medium supplemented with 50 µM GM6001 and 0.5% DMSO (Abcam, ab120845) or with 0.5% DMSO only (control condition). For myosin inhibition experiments (Fig. S2), C855a-Gal4

(9) Matrix metalloproteinases (MMPs) mediate leukocyte recruitment during the inflammatory phase of zebrafish heart regenerationScientific ReportsDecember 1, 2018Shisan Xu, Sarah E. Webb, Terrence Chi Kong Lau, Shuk Han ChengBethesda, MA, USA). GM6001 and MMP9/MMP13 inhibitor I treatment, and chemokine injection GM6001 (ab120845; Abcam) and MMP9/MMP13 inhibitor I (21265; Cayman) were prepared at a stock concentration of 20 mM in

(10) MMP proteolytic activity regulates cancer invasiveness by modulating integrinsScientific ReportsDecember 1, 2017Alakesh Das, Melissa Monteiro, Amlan Barai, Sandeep Kumar, Shamik Senspreading, cells were allowed to adhere on to the gels for 20 mins, after which GM6001 (Abcam, Cat # ab120845) was added at a concentration of 10 μM for 12–15 hrs. Untreated cells and DMSO (MP biomedical, Cat #

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GM 6001, MMP inhibitor from Abcam

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GM 6001, MMP inhibitor from Abcam

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