Description
A PDE3A inhibitor (IC50 = 0.2 µM for the platelet enzyme); selective for PDE3A over PDE1, -2, -4, and 5 (IC50s = >5 µM for all); inhibits collagen- or ADP-induced aggregation of isolated rabbit platelets (IC50s = 29 and 31 µM, respectively); reduces thrombus formation by 84% in a mouse model of pulmonary thromboembolism at 30 mg/kg