Stattic, STAT3 inhibitor from Abcam

Product Specs
ItemStattic, STAT3 inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120952
Quantity10 MG, 50 MG
Purity0.99
Typeinhibitor

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) Chemo-preventive effects and antitumorigenic mechanisms of beer and nonalcoholic beer toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) - induced lung tumorigenesis in A/J miceGenes and EnvironmentJune 7, 2023Jun Takata, Katsuyuki Kiura, Takamasa Nakasuka, Atsuko Hirabae, Sakae Arimoto-KobayashiLY294002 (#9901) monoclonal antibodies (mAbs) was purchased from CST, Japan (Tokyo, Japan), and Stattic (ab120952) from Abcam (Cambridge, UK). All the other reagents were purchased from commercial sources. Salmonella enterica

(2) Cationic amphiphilic antihistamines inhibit STAT3 via Ca2+-dependent lysosomal H+ effluxCell ReportsFebruary 17, 2023Bin Liu, Ran Chen, Yidan Zhang, Jinrong Huang, Yonglun Luo, Susanne Rosthøj, Chenyang Zhao, Marja JäätteläA3085 Ebastine,Cayman Chemical,Cat# T9652 WP1066,Merk,Cat# N3510 STA-21,Selleckchem,Cat# S7951 Stattic,Abcam,Cat# Ab120952 "Hoechst 33,342",Sigma Aldrich,Cat# B2261 Propidium iodide solution,Sigma Aldrich,Cat# P4864 "Dextran, Fluorescein, 70,000 MW, Anionic

(3) Silibinin induces immunogenic cell death in cancer cells and enhances the induced immunogenicity by chemotherapyBioImpactsJanuary 1, 2023Sevda Jafari, Saba Heydarian, Raymond Lai, Elnaz Mehdizadeh Aghdam, Ommoleila Molavirespectively from Ontario Chemicals Inc. (Ontario, Canada), Sigma-Aldrich (St. Louis, MO, USA), and Abcam (ab120952, USA). FITC Annexin V–PI apoptosis staining kit and mouse interleukin-12 (IL-12) p70 Elisa kit (cat.

(4) Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress, and extracellular vesicle release in vascular smooth muscle cellsCardiovascular ResearchJuly 20, 2022Ploingarm Petsophonsakul et al.N-acetyl-cysteine (0.5 µM, Sigma, A7250), Vitamin K (Menaquinone-7, 10 µM, Nattopharma ASA), Stattic (1 µM, Abcam, ab120952), SU6656-SrcFK inhibitor (2 µM, Sigma, S9692), GSK2656157-pERK inhibitor (2 µM, ApexBio, B2175), and

(5) Macrophage IL-1β promotes arteriogenesis by autocrine STAT3- and NF-κB-mediated transcription of pro-angiogenic VEGF-ACell reportsFebruary 1, 2022Mantsounga CS, Lee C, Neverson J, Sharma S, Healy A, Berus JM, Parry C, Ceneri NM, López-Giráldez F, Chun HJ, et al.cat.575904) up to 24 hours. In some experiments, BMDMs were treated with the STAT3 inhibitor, Stattic (Abcam, ab120952), or the NF-κB inhibitor, JSH23 (Abcam, ab144824). Hindlimb ischemia model Femoral artery ligation

(6) CCL5 Suppresses Klotho Expression via p-STAT3/DNA Methyltransferase1-Mediated Promoter HypermethylationFrontiers in physiologyJanuary 1, 2022Liu Q, Li S, Yu L, Yin X, Liu X, Ye J, Lu G.CCL5 (sc-4,637, Santa Cruz) for 24 h. To verify the effect of STAT3, STAT3 inhibitor stattic (10 μM, ab120952, Abcam) was applied. To verify the effect of DNMT1, DNMT1 inhibitor 5-Aza (10 μM) was applied. Cells

(7) The Circadian Clock Protein BMAL1 Acts as a Metabolic Sensor In Macrophages to Control the Production of Pro IL-1βFrontiers in ImmunologyNovember 9, 2021George A. Timmons et al.purchased from Sigma. Disuccinimidyl suberate (DSS) (21655) was purchased from Thermo Scientific. Stattic (AB120952) was purchased from Abcam. DASA-58 (HY-19330) was purchased from MedChemExpress. Culture of Mouse Bone

(8) Integrin α5 promotes migration and invasion through the FAK/STAT3/AKT signaling pathway in icotinib‑resistant non‑small cell lung cancer cellsOncology LettersMay 24, 2021Yang Yang, Yizhe Wang, Xiaofang Che, Kezuo Hou, Jie Wu, Chunlei Zheng, Yang Cheng, Yunpeng Liu, Xuejun Hu, Jingdong Zhangwas prepared in 5% dimethyl sulfoxide to obtain a stock solution of 10 mM at ‑20˚C. Stattic (cat. no. ab120952) was obtained from Abcam, used in western blot as an inhibitor of STAT3. Anti‑AKT (1:1,000; cat. no.

(9) Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunctionJournal of Molecular EndocrinologyMay 1, 2021Zuo Zhang, Hongli Zhou, Jiyin Zhouhuman neuritin (Sigma Co. Ltd.), JAK2 inhibitor (AG490), and STAT3 inhibitor (Stattic, Abcam Catalog #ab120952) were administered 30 min before stimulation with 1 μg/mL lipopolysaccharide. After 48 h of treatment,

(10) ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancerCancer scienceMarch 1, 2021Katsurahara K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, et al.(ab246145). We purchased IFNα from EnoGene Biotechnology (E6L00101) and STAT3 inhibitor from Abcam (ab120952). 2.2 Western blotting Cells were washed twice with ice‐cold PBS and lysed in M‐PER buffer (Pierce)

(11) Interleukin-17A derived from mast cells contributes to fibrosis in gastric cancer with peritoneal disseminationGastric CancerJanuary 1, 2021Katsuya Gunjigake et al.(USA) and reconstituted in RPMI-1640 medium at appropriate concentrations. Sttatic STAT3 inhibitor (ab120952) was purchased from Abcam and reconstituted in DMSO to 50 mM. Mouse xenograft model All animal experiments

(12) Ubiquitin-Specific Protease 25 Aggravates Acute Pancreatitis and Acute Pancreatitis-Related Multiple Organ Injury by Destroying Tight Junctions Through Activation of The STAT3 PathwayFrontiers in cell and developmental biologyJanuary 1, 2021Liu Z, Qi M, Tian S, Yang Q, Liu J, Wang S, Ji M, Yu R, Zeng S, Li J, et al.same amount of phosphate buffered saline (PBS). Inhibition of STAT3 Activation With Stattic Stattic (ab120952, Abcam, Cambridge, UK) was administered to mice at a dose of 1 mg/kg/day per mouse for 7 days to inhibit

(13) Promotion of Adropin Expression by Hyperglycemia Is Associated with STAT3 Activation in Diabetic RatsDiabetes, Metabolic Syndrome and Obesity: Targets and TherapyJune 29, 2020Feng Yu Kuo, Kai-Chun Cheng, Yingxiao Li, Juei-Tang Cheng, Cheng-Chia Tsaiused both in vitro and in vivo.13 To investigate the interaction between adropin and STAT3, Stattic (ab120952, Abcam, Cambridge, UK) at indicated doses (1 mg/kg/day or 2 mg/ kg/day) or vehicle were intravenously

(14) A critical role of E2F transcription factor 2 in proinflammatory cytokines-dependent proliferation and invasiveness of fibroblast-like synoviocytes in rheumatoid ArthritisScientific ReportsDecember 1, 2018Rui Zhang, Lin Wang, Ji-hong Pan, Jinxiang Hanab120234), or Static (an inhibitor of signal transducers and activators of transcription (STAT3), Abcam, ab120952), respectively. For the siRNA blocking assay, 0, 1, 10, 50 ng/ml of TNF-α with or without 100 nmol/l

(15) Therapeutic potential of targeting S100A11 in malignant pleural mesotheliomaOncogenesisJanuary 24, 2018Sato H, Sakaguchi M, Yamamoto H, Tomida S, Aoe K, Shien K, Yoshioka T, Namba K, Torigoe H, Soh J, et al.

(16) Wnt/β-Catenin-Promoted Macrophage Alternative Activation Contributes to Kidney FibrosisJournal of the American Society of Nephrology : JASNJanuary 1, 2018Feng Y, Ren J, Gui Y, Wei W, Shu B, Lu Q, Xue X, Sun X, He W, Yang J, et al.100-B-010-CF; R&D Systems). To block STAT3 signaling, BMMs were treated with Stattic (10 mM; catalog no. ab120952; Abcam, Cambridge, United Kingdom) for 30 minutes, and then, they were treated with Wnt3a (100 ng/ml)

(17) Proprotein convertase subtilisin/kexin type 6 promotes in vitro proliferation, migration and inflammatory cytokine secretion of synovial fibroblast-like cells from rheumatoid arthritis via nuclear-κB, signal transducer and activator of transcription 3 and extracellular signal regulated 1/2 pathwaysMolecular Medicine ReportsDecember 1, 2017Huiyu Jiang, Lin Wang, Feifei Wang, Jihong Panpyrrolidine dithiocarbamate (PDTC; cat. no. ab141406; Abcam), the STAT inhibitor stattic (cat. no. ab120952 Abcam), or the ERK‑1/2 inhibitor PD98059 (cat. no. ab120234, Abcam) was added to cells in the presence

(18) Long non-coding RNA00364 represses hepatocellular carcinoma cell proliferation via modulating p-STAT3-IFIT2 signaling axisOncotargetNovember 24, 2017Tang WG, Hu B, Sun HX, Sun QM, Sun C, Fu PY, Yang ZF, Zhang X, Zhou CH, Fan J, et al.

(19) Lung damage induced by hyperglycemia in diabetic rats: The role of signal transducer and activator of transcription 3 (STAT3)Journal of Diabetes and Its ComplicationsJuly 13, 2016Ching-Min Wang, Chao-Tien Hsu, Ho-Shan Niu, Chin-Hong Chang, Juei-Tang Cheng, Jiunn-Min Shieh

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Stattic, STAT3 inhibitor from Abcam

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Stattic, STAT3 inhibitor from Abcam

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