JC-1, Mitochondrial membrane potential dye from Abcam

Product Specs
ItemJC-1, Mitochondrial membrane potential dye
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab141387
Quantity5 mg
Purity0.98

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) HADHA alleviates hepatic steatosis and oxidative stress in NAFLD via inactivation of the MKK3/MAPK pathwayMolecular Biology ReportsFebruary 1, 2023Jiexia Ding, Lili Wu, Guoxian Zhu, Jing Zhu, Pingping Luo, Youming Liand liver tissues Mitochondrial depolarization was analysed with an MMP assay kit with JC-1 (Abcam, ab141387) according to the manufacturer’s instructions. Mitochondrial JC-1 monomers (green) and aggregates (red)

(2) SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1Cell death and differentiationFebruary 1, 2023Wang D, Liang W, Huo D, Wang H, Wang Y, Cong C, Zhang C, Yan S, Gao M, Su X, et al.Mitochondrial membrane potential (MMP) was detected through incubation with the JC-1 fluorescence probe (5 μM, Abcam, ab141387) but followed by the analysis using a flow cytometer (FC500, Beckmancoulter, USA). JC-1 aggregates showed

(3) Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex INatureJuly 1, 2022Rodríguez-Nuevo A, Torres-Sanchez A, Duran JM, De Guirior C, Martínez-Zamora MA, Böke E.tetramethylrhodamine ethyl ester perchlorate (TMRE) (Thermo, T669), or 45 min in 4 µM JC-1 (Abcam, ab141387). Cells were then washed and imaged in 35-mm glass-bottom MatTek dishes. Oxygen consumption rate Oxygen

(4) Inhibition of miR-421 Preserves Mitochondrial Function and Protects against Parkinsonâ€™s Disease Pathogenesis via Pink1/Parkin-Dependent MitophagyDisease MarkersMay 10, 2022Xiaolin Dong, Xianghua He, Li Yang, Qingyun Li, Yanming XuMeasurement The Δψm was analyzed by measuring the fluorescence intensity of cells stained with JC-1 dye (Abcam, ab141387). SH-SY5Y cells were trypsinized, washed with PBS buffer, and resuspended in DMEM. SH-SY5Y cells were

(5) Ginsenoside Rg3 alleviates septic liver injury by regulating the lncRNA TUG1/miR-200c-3p/SIRT1 axisJournal of inflammation (London, England)December 20, 2021Wu P, Yu X, Peng Y, Wang QL, Deng LT, Xing W.(Ex/Em = 510/580 nm). Detection of mitochondrial transmembrane potential (MTP) JC-1 (CBIC2) dye (ab141387, Abcam) was employed to measure the MTP of human primary hepatocytes. JC-1 (10 μM) in DMEM was added

(6) Inhibition of Autophagy Prevents Panax Notoginseng Saponins (PNS) Protection on Cardiac Myocytes Against Endoplasmic Reticulum (ER) Stress-Induced Mitochondrial Injury, Ca²⁺ Homeostasis and Associated ApoptosisFrontiers in pharmacologyJanuary 1, 2021Chen J, Li L, Bai X, Xiao L, Shangguan J, Zhang W, Zhang X, Wang S, Liu G.assessed using 5, 5′, 6, 6′-tetrachloro-1, 1′, 3, 3′-tetraethylbenzimidazolyl-carbocyanine iodide (JC-1) (ab141387, Abcam, United States). In details, cardiomyocytes were seeded in a 96-well black frame plate at the

(7) Mir-141-3p Regulates Apoptosis and Mitochondrial Membrane Potential via Targeting Sirtuin1 in a 1-Methyl-4-Phenylpyridinium in vitro Model of Parkinson’s DiseaseBioMed Research InternationalNovember 6, 2020Yumin Zheng, Li Dong, Na Liu, Xiaoguang Luo, Zhiyi HePotential. Δψm was analyzed via measuring the ﬂuorescent intensity of cells stained with JC-1 dye (ab141387, Abcam, Cambridge, UK). The PC12 cells were treated with trypsin, washed with PBS buﬀer, and resuspended

(8) Structure-function relationships of HDL in diabetes and coronary heart diseaseJCI insightJanuary 16, 2020Cardner M, Yalcinkaya M, Goetze S, Luca E, Balaz M, Hunjadi M, Hartung J, Shemet A, Kränkel N, Radosavljevic S, et al.of HDL for an additional 2 hours. MMP was monitored using the JC-1 fluorescent dye (Abcam, catalog ab141387) that accumulates in mitochondria in a voltage-dependent manner (dye was loaded for 30 minutes prior

(9) Sulfated polysaccharide of Sepiella maindroni ink targets Akt and overcomes resistance to the FGFR inhibitor AZD4547 in bladder cancerAgingSeptember 23, 2019Shan L, Liu W, Zhan Y.and cells were then harvested and stained with the mitochondrial membrane potential reporter JC-1 (ab141387, Abcam, Cambridge, UK). JC-1 fluorescence was assessed by flow cytometry in three individual experiments. Xenograft

(10) Active Vitamin D and Vitamin D Receptor Help Prevent High Glucose Induced Oxidative Stress of Renal Tubular Cells via AKT/UCP2 Signaling PathwayBioMed research internationalJanuary 1, 2019Zhu X, Wu S, Guo H.to wash the cells. The cells were incubated with ROS (MA5-26760, Life technologies), JC-1 antibody (ab141387, Abcam) and Annexin V/PI(556547, BD)at room temperature for 30 min, and flow cytometry analysis was

(11) Soluble guanylate cyclase activation during ischemic injury in mice protects against postischemic inflammation at the mitochondrial levelAmerican Journal of Physiology-Gastrointestinal and Liver PhysiologyMay 1, 2016Derek Z. Wang, Allan W. Jones, Walter Z. Wang, Meifang Wang, Ronald J. KorthuisHEPES-HCO3-buffered salt solution, as in our previous study (29). The suspension was incubated with 4 ␮g/ml JC-1 (ab141387; Abcam) for 15 min in the dark at room temperature. The fluorescence was measured in duplicate at excitation/emission

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JC-1, Mitochondrial membrane potential dye from Abcam

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JC-1, Mitochondrial membrane potential dye from Abcam

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