Description
A staurosporine analog that inhibits PKC, PKA, CaMKII, and phosphorylase kinase (IC50s = 470, 140, 270, and 1.7 nM, respectively); inhibits PRK1 (IC50 = 3.2 nM in vitro), a PKC-related kinase that phosphorylates histone H3 at threonine 11