Wortmannin from MedChemExpress

Product Specs
ItemWortmannin
CompanyMedChemExpress
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberHY-10197
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.86%
TypeChemical
Molecular Weight428.43
FormulaC₂₃H₂₄O₈
Research AreaCancer

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(1) Macropinocytosis in Gracilariopsis lemaneiformis (Rhodophyta)Frontiers in Plant ScienceSeptember 26, 2023Haihong Chen, Yiyi Hu, Guanpin Yang, Pingping Li, Jingru Yin, Xiaoqing Feng, Qiong Wu, Jingyu Zhang, Baoheng Xiao, Zhenghong Sui(MedChemExpress, Cat. HY-101840), lacunculin B (Aladdin, Cat. L275457), and wortmannin (MedChemExpress, Cat. HY-10197) were incubated with slices for 1 h, and then, the slices were incubated with the mixture of inhibitors

(2) EP1 activation inhibits doxorubicin-cardiomyocyte ferroptosis via Nrf2Redox BiologySeptember 1, 2023Bei Wang, Yuxuan Jin, Jiao Liu, Qian Liu, Yujun Shen, Shengkai Zuo, Ying Yu(#S5742) and ML-385 (#S8790) were purchased from Selleck Chemicals (Houston, TX, USA). Wortmannin (#HY-10197), SP600125 (#HY-12041), and Ravoxertinib (#HY-15947) were purchased from MedChemExpress (MCE) Company

(3) Tubeimoside-2 Triggers Methuosis in Hepatocarcinoma Cells through the MKK4–p38α AxisPharmaceuticsMarch 29, 2023Yichao Gan, Chen Wang, Yunyun Chen, Linxin Hua, Hui Fang, Shu Li, Shoujie Chai, Yang Xu, Jiawei Zhang, Ying GuSelleck Chemicals(Houston, TX, USA); other small molecular inhibitors, 3-methyladenine (Cat# HY-19312), Wortmannin (Cat# HY-10197), EIPA (Cat# HY-101840), PD 169,316 (Cat# HY-10578), EHop-016 (Cat# HY-12810), and EHT 1864 (Cat# HY-16659)

(4) Targeting CRL4 suppresses chemoresistant ovarian cancer growth by inducing mitophagySignal transduction and targeted therapyDecember 9, 2022Meng Y, Qiu L, Zeng X, Hu X, Zhang Y, Wan X, Mao X, Wu J, Xu Y, Xiong Q, et al.under 5% CO2. Cisplatin was purchased from J&K Scientific Ltd. (15663-27-1, China). Wortmannin (MCE, HY-10197, USA) and 3-methyladenine (3-MA) (MCE, HY-19312, USA) were purchased from MedChemExpress. Antibodies The

(5) Salidroside Ameliorates Ultraviolet-Induced Keratinocyte Injury by Inducing SIRT1-Dependent AutophagyClinical, Cosmetic and Investigational DermatologyAugust 2, 2022Jin Ke, Jie Wang, Xing Wu, Yuehua YanSAL for 2 h and exposed to UVB. In some experiments, cells were also co-incubated with Wortmannin (HY-10197, MedChemExpress) or EX-527 (HY-15452, MedChemExpress). Cells were washed with PBS and incubated with

(6) ROS generation attenuates the anti-cancer effect of CPX on cervical cancer cells by inducing autophagy and inhibiting glycophagyRedox BiologyJuly 1, 2022Hui Fan et al.purchased from Sigma. Bafilomycin A1 (HY-100558), CQ (HY-17589A), Compound C (HY-13418), Wortmannin (HY-10197), Cycloheximide (HY-12320) were purchased from MedChemExpress. NAC (Beyotime, ST1546). 2.3 Cell viability

(7) TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent mannerRedox BiologyJuly 1, 2022Mengru Liu et al.with the inhibitor, chloroquine (50 μM, Sigma, C6628), for 4 h. 100 nM wortmannin (MedChemExpress, HY-10197) or 3 μM ML385 (Selleck, S8790) was added during OGD-Rep. 2.5 Plasmid transfection and RNA silencing Primary

(8) Endocytic trafficking promotes vacuolar enlargements for fast cell expansion rates in plantseLifeJune 10, 2022Kai DÃ¼nser, Maria SchÃ¶ller, Ann-Kathrin RÃ¶ÃŸling, Christian LÃ¶fke, Nannan Xiao, Barbora PaÅ™ÃzkovÃ¡, Stanislav Melnik, Marta Rodriguez-Franco, Eva StÃ¶ger, OndÅ™ej NovÃ¡k, et al.acetoxymethyl ester (BCECF-AM) (cat. no. 51012) from Biotium (Fremont, CA), Wortmannin (WM) (cat. no. HY-10197) from MedChemExpress (Princeton, NJ) and BFA (cat. no. J62340) from Alfa Aesar (Tewksbury, MA). VAC1

(9) Cytoplasmic domain and enzymatic activity of ACE2 are not required for PI4KB dependent endocytosis entry of SARS-CoV-2 into host cellsVirologica SinicaJune 1, 2022Yang H, Yuan H, Zhao X, Xun M, Guo S, Wang N, Liu B, Wang H.purchased from Sigma. Pitstop (#ab120685) was purchased from Abcam. PIK93 (#HY-12046), Wortmannin (#HY-10197), camostat mesylate (#HY-13512) and E−64d (#HY-100229) were purchased from MedChemExpress. 2.3 Pseudovirus

(10) EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis modelThe Journal of experimental medicineMay 2, 2022Tao X, Zhang R, Du R, Yu T, Yang H, Li J, Wang Y, Liu Q, Zuo S, Wang X, et al.Laboratories (#180), and U73122 (#HY-13419), PMA (#HY-18739), melittin (#HY-P0233), and wortmannin (#HY-10197) were purchased from MedChemExpress. Sotrastaurin was purchased from Selleckchem (#S2791). Phalloidin

(11) Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidatesActa Pharmacologica SinicaApril 1, 2022Yi Wang, Sui Fang, Yan Wu, Xi Cheng, Lei-ke Zhang, Xu-rui Shen, Shuang-qu Li, Jian-rong Xu, Wei-juan Shang, Zhao-bing Gao, et al.Chinese National Compound Library (~2300 compounds). Veliparib (HY-10129, CAS No. 912444-00-9), wortmannin (HY-10197, CAS No. 19545-26-7), proanthocyanidins (HY-N0794, CAS No. 4852-22-6) were purchased from MedChemExpress

(12) ACAGT-007a, an ERK MAPK Signaling Modulator, in Combination with AKT Signaling Inhibition Induces Apoptosis in KRAS Mutant Pancreatic Cancer T3M4 and MIA-Pa-Ca-2 CellsCellsFebruary 17, 2022Golam Iftakhar Khandakar, Ryosuke Satoh, Teruaki Takasaki, Kana Fujitani, Genzoh Tanabe, Kazuko Sakai, Kazuto Nishio, Reiko SugiuraU0126 (U-6770) was purchased from LC Laboratories (Woburn, MA, USA) and dissolved in DMSO. Wortmannin (HY-10197) was purchased from MedChemExpress (Monmouth Junction, NJ, USA) and dissolved in DMSO. Perifosine (P-6522)

(13) Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergismScience advancesJanuary 21, 2022Krstic J, Reinisch I, Schindlmaier K, Galhuber M, Riahi Z, Berger N, Kupper N, Moyschewitz E, Auer M, Michenthaler H, et al.were used: SCH772984 ERK1/2 inhibitor (Cayman Chemicals); U0126 MEK inhibitor (Promega); wortmannin (HY-10197), buparlisib (HY-70063), and MK-2206 dihydrochloride (HY-10358), all from MedChemExpress; bafilomycin A1

(14) Innate/Inflammatory Bioregulation of Surfactant Protein D Alleviates Rat Osteoarthritis by Inhibiting Toll-Like Receptor 4 SignalingFrontiers in immunologyJanuary 1, 2022Jiang H, Zhang Y, Hu G, Shang X, Ming J, Deng M, Li Y, Ma Y, Liu S, Zhou Y.TLR4 inhibitor TAK-242 (#614316) was obtained from Calbiochem (San Diego, CA, USA). The PI3K inhibitor wortmannin (#HY-10197) was obtained from MedChemExpress (New Jersey, USA). Collagen II (#28459-1-AP) was obtained from Proteintech Group

(15) CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formationMolecular psychiatryNovember 1, 2021Ajoy R, Lo YC, Ho MH, Chen YY, Wang Y, Chen YH, Jing-Yuan C, Changou CA, Hsiung YC, Chen HM, et al.treatments after 4 hr seeding and attachment, including CCL5, AICAR, MetCCL5, or PI3K inhibitor––Wortmannin (HY-10197. MedChemExpress, NJ, USA) and BLY-719 (HY-15244. MedChemExpress, NJ, USA) as well as both Wortmannin

(16) PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesisNature communicationsJune 8, 2021Yin S, Liu L, Brobbey C, Palanisamy V, Ball LE, Olsen SK, Ostrowski MC, Gan W.E1383) cisplatin (Sigma, 232120), LY294002 (MedChemExpress, HY-10108), Wortmannin (MedChemExpress, HY-10197), and Buparlisib (MedChemExpress, HY-70063) were used at the indicated doses. PI(3,4,5)P3 beads (P-B345A-2),

(17) A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like modelsTheranosticsMarch 11, 2021Weijin Wang et al.aliquots (10 mM dissolved in 99.7% DMSO, 10 μL) were stored at -80 ºC. Wortmannin (WO, MedChemExpress, HY-10197, Molecular Weight: 428.43) stock aliquots (10 mM dissolved in 99.7% DMSO, 10 μL) were stored at -80

(18) BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responsesPLoS pathogensMarch 1, 2020Wang J, Li GL, Ming SL, Wang CF, Shi LJ, Su BQ, Wu HT, Zeng L, Han YQ, Liu ZH, et al.5-Azacytidine (HY-10586), JQ-1 (HY-13030), OTX-015 (HY-15743), I-BET151 (HY-13235) and wortmannin (HY-10197) were from MedChemExpress. Lipofectamine 3000 (L3000015), CellMask Green (C37608) and CellMask Deep Red

(19) "Ultrastructural alteration of cytolytic T lymphocytes following their interaction with target cells. III. Plasmalemma, ""membranosomas"""Cellular immunologyJanuary 1, 1979Bykovskaja SN, Rytenko AN, Rauschenbach MO, Bykovsky AF.

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Wortmannin from MedChemExpress

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Wortmannin from MedChemExpress

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