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Protein Biochemistry
Chemicals and Reagents
H-89, Dihydrochloride
H-89, Dihydrochloride from Cell Signaling Technology
Be the first to write a review!
Citations:
(22)
Supplier Page
Supplier Page from
Cell Signaling Technology for
H-89, Dihydrochloride
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
H-89, Dihydrochloride
Company
Cell Signaling Technology
Price
Pricing Info
Supplier Page
View Company Product Page
Catalog Number
9844S
Applications
W
Quantity
5.19 mg
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Cell Signaling Technology
3 Trask Lane
Danvers
,
Massachusetts
01923
United States
Phone
: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488
Company Profile
Website:
http://www.cellsignal.com/
Website:
Technical Support
Citations (22)
(1)
Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells
Cell reports
May 30, 2023
Xu W, Qadir MMF, Nasteska D, Mota de Sa P, Gorvin CM, Blandino-Rosano M, Evans CR, Ho T, Potapenko E, Veluthakal R,
et al
.
F3917
GIP,Tocris,Cat# 2084
Glucagon
,
Sigma Aldrich
,Cat#
G2044
DHT,Steraloids,Cat# A2570-000 H89,
CST
,Cat#
9844
ESI-09,Sigma Aldrich,Cat# SML0814 LRE1,Sigma Aldrich,Cat# SML1857
KH7
,
Sigma Aldrich
,Cat#
K3394
TDI-10229,Cornell,N/A
Acetazolamide
(2)
Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation
Nature communications
December 8, 2022
Zhang X, Luo S, Wang M, Cao Q, Zhang Z, Huang Q, Li J, Deng Z, Liu T, Liu CL,
et al
.
cells were starved for 8 hrs, followed by treating cells with 100 ng/mL
IL18
with or without 20 µM H89 (
9844
S,
Cell Signaling Technology
) for 30 min. Human adipose tissue from two donors were used in this study
(3)
A new type of ERGIC-ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis
Cell research
February 1, 2022
Li S, Yan R, Xu J, Zhao S, Ma X, Sun Q, Zhang M, Li Y, Liu JG, Chen L,
et al
.
S6494),
Cycloheximide
(
CST
,
2112S
),
Bafilomycin A1
(
Selleck
,
S1413
), Rapamycin (
Sigma
,
R8781
), H89 (
CST
,
9844
). Other reagents were described previously.61,68 l-amino acid peptides were synthesized by Scilight
(4)
In Vitro Study of Licorice on IL-1β-Induced Chondrocytes and In Silico Approach for Osteoarthritis
Pharmaceuticals (Basel, Switzerland)
December 20, 2021
Ali A, Park Y, Lee J, An HJ, Jin JS, Lee JH, Chang J, Kim DK, Goo B, Park YC,
et al
.
Sigma-Aldrich
(St. Louis, MO, USA).
Recombinant Human IL-1β
from
PeproTech
(Cranbury, NJ, USA). H89 (#
9844
) and Okadiac acid (#
5934
) from
Cell Signaling Technology
(Bervely, MA, USA).
Parathyroid Hormone (7-34), Human Recombinant
(5)
Restraint stress induces uterine microenvironment disorder in mice during early pregnancy through the β
2
-AR/cAMP/PKA pathway
Stress
September 3, 2021
Jiayin Lu, Guanhui Liu, Zixu Wang, Jing Cao, Yaoxing Chen, Yulan Dong
agonist; 66575-29-9, Tocris Bioscience, MN, USA; 0.1 µM, 1 µM, or 10 µM), H-89 (a selective
inhibitor
of PKA; #
9844
,
Cell Signaling Technology
, MA, USA; 0.1 µM, 1 µM, or 10 µM),
PD98059
(a selective
inhibitor
of ERK;
(6)
β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes
PloS one
January 1, 2020
Hattori K, Wakatsuki H, Sakauchi C, Furutani S, Sugawara S, Hatta T, Natsume T, Ichijo H.
norepinephrine (A9512) were purchased from
Sigma-Aldrich
. H89 was purchased from
Cell Signaling Technology
(#
9844S
) or
Cayman Chemical
(#
10010556
). 8-pCPT-cAMP (#039–18121) and H2O2 (#081–04215) were purchased from
(7)
Cascade Signals of Papaverine Inhibiting LPS-Induced Retinal Microglial Activation
Journal of Molecular Neuroscience
May 1, 2019
Ting Zhou, Yu Zhu
pretreated with cAMP
inhibitor
Rp-isomer(200 μmol,C0735-1VL,Sigma, USA), PKA
inhibitor
H89(5 μmol,
9844
,
CST
) and Erk inhibitor
U0126
(10 μmol, HY-12031,MCE) for 1 h, papaverine (10 μg/ml,120,901–1, Northeast
(8)
CXCL12-CXCR4 pathway activates brown adipocytes and induces insulin resistance in CXCR4-deficient mice under high-fat diet
Scientific reports
April 16, 2019
Kurita K, Ishikawa K, Takeda K, Fujimoto M, Ono H, Kumagai J, Inoue H, Yokoh H, Yokote K.
Cell Signalling
Technology) as a
P38
inhibitor
, FR180204 (#0320;
Sigma-Aldrich
) as an
ERK inhibitor
, and H89 (#
9844
;
Cell Signalling
Technology) as a PKA
inhibitor
were adjusted to a final concentration of 10, 25, and
(9)
The GABA
A
Receptor α2 Subunit Activates a Neuronal TLR4 Signal in the Ventral Tegmental Area that Regulates Alcohol and Nicotine Abuse
Brain sciences
April 21, 2018
Balan I, Warnock KT, Puche A, Gondre-Lewis MC, June H, Aurelian L.
µg/well of a 6-well plate). The PKA-specific
inhibitor
H89 (10 μM;
Cell Signaling Technology
, Cat. #
9844
) and the
TLR4
-specific ligand
LPS
(1 μg/mL; Sigma-Aldrich, St. Louis, MO, USA, Cat. # L3024) were added
(10)
PER, a Circadian Clock Component, Mediates the Suppression of MMP-1 Expression in HaCaT Keratinocytes by cAMP
Molecules (Basel, Switzerland)
March 23, 2018
Yeom M, Lee H, Shin S, Park D, Jung E.
cells were treated with 1 and 10 µM FSK or 10 µM H-89 purchased from
Cell signaling technology
(#
3828
, #
9844
, Danvers, MA, USA). After 24 h of treatment, cells were harvested for analyzing mRNA expression. For
(11)
Innately activated TLR4 signal in the nucleus accumbens is sustained by CRF amplification loop and regulates impulsivity
Brain, behavior, and immunity
March 1, 2018
Balan I, Warnock KT, Puche A, Gondre-Lewis MC, Aurelian L.
Minneapolis, MN, USA, Cat. #
2778
), the PKA-specific
inhibitor
H89 (10 µM;
Cell Signaling Technology
, Cat. #
9844
), and the specific
inhibitor
of MAPK extracellular signaling regulated kinase (
ERK
) kinase (MEK),
U0126
(12)
Orphan Adhesion GPCR GPR64/ADGRG2 Is Overexpressed in Parathyroid Tumors and Attenuates Calcium-Sensing Receptor-Mediated Signaling
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
March 1, 2017
Balenga N, Azimzadeh P, Hogue JA, Staats PN, Shi Y, Koh J, Dressman H, Olson JA Jr.
(
Sigma
; #
P8761
), calcium chloride (Sigma; #21115), H-89 (Cell Signaling Technologies, Beverly, MA, USA; #
9844
),
U0126
(
Cell Signaling Technologies
; #
9903
), collagenase (
Sigma
; #
C2674
), zeocin (
Thermo Fisher Scientific
,
(13)
Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
Nature communications
February 7, 2017
Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T,
et al
.
Sigma-Aldrich
, St. Louis, MO, USA. Forskolin (catalogue #:
3828
) and dihydrochloride (H-89, catalogue #: #
9844
) were from
Cell Signalling
, Danvers, MA, USA. MG132 (catalogue #:
sc-201270
) and
Bortezomib
(catalogue
(14)
Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4
Proceedings of the National Academy of Sciences
January 31, 2017
Maria Castañeda-Bueno, Juan Pablo Arroyo, Junhui Zhang, Jeremy Puthumana, Orlando Yarborough, Shigeru Shibata, Lorena Rojas-Vega, Gerardo Gamba, Jesse Rinehart, Richard P. Lifton
(
Cell Signaling Technology
#
9841
), TPA (
Cell Signaling Technology
#
4174
),
H-89, Dihydrochloride
(
Cell Signaling Technology
#
9844
), and forskolin (
Cell Signaling Technology
#
3828
), drugs were added to the culture media 30 min before
(15)
Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression
Theranostics
January 1, 2017
Li X, Chen W, Li P, Wei J, Cheng Y, Liu P, Yan Q, Xu X, Cui Y, Gu Z,
et al
.
MDL12330A(#1436) were obtained from Tocris Bioscience (Minneapolis, MN, USA).
LY294002
(LY, #
9901s
) and H89 (#
9844s
) were acquired from
Cell Signaling Technologies
(CST, Beverly, MA, USA). Endothelial Basal Medium-2
(16)
TLR4 signaling in VTA dopaminergic neurons regulates impulsivity through tyrosine hydroxylase modulation
Translational psychiatry
May 17, 2016
Aurelian L, Warnock KT, Balan I, Puche A, June H.
(pCREB; Ser-133; Cat. #
9198
) and phospho-PKA (pPKA; Thr197; Cat. #
4781
) and the PKA
inhibitor
H89 (Cat. #
9844
) were from
Cell Signaling Technology
(Danvers, MA, USA). Other antibodies were
mouse
anti-TH (
EMD Millipore
,
(17)
ASK1 signalling regulates brown and beige adipocyte function
Nature communications
April 5, 2016
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H.
isoproterenol (
I6504
), norepinephrine (A9512) and
Oil red O
(O0625) were purchased from
Sigma
. H89 (#
9844S
) was purchased from
Cell Signalling
. 8-pCPT-cAMP (039-18121) and H2O2 (081-04215) were purchased from
(18)
β2-adrenergic signal transduction plays a detrimental role in subchondral bone loss of temporomandibular joint in osteoarthritis
Scientific Reports
December 1, 2015
Kai Jiao, Li-Na Niu, Qi-hong Li, Gao-tong Ren, Chang-ming Zhao, Yun-dong Liu, Franklin R. Tay, Mei-qing Wang
118,551 (0821, R&D Systems, Minneapolis, MN, USA), a specific β2-adenoreceptor antagonist, 5 μM H-89 (
9844
,
Cell Signaling Technology
, Inc., Danvers, MA,USA), a selective PKA
inhibitor
, or 5 μM U-0126 (
9903
,
(19)
Role of LRP1 and ERK and cAMP Signaling Pathways in Lactoferrin-Induced Lipolysis in Mature Rat Adipocytes
PLOS ONE
October 27, 2015
Keiko Ikoma-Seki, Kanae Nakamura, Satoru Morishita, Tomoji Ono, Keikichi Sugiyama, Hoyoku Nishino, Hisashi Hirano, Michiaki Murakoshi
cultures. The PKA signal inhibition
assay
was performed with or without 40 mM of
H-89, dihydrochloride
(#
9844
,
Cell Signaling Technology
Japan, K.K., Tokyo, Japan) in the
assay
medium described above. Cells were
(20)
Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic ß-cells via protein kinase A
Molecular Metabolism
February 3, 2015
Sindhu Rajan, Lorna M. Dickson, Elizabeth Mathew, Caitlin M.O. Orr, Johanne H. Ellenbroek, Louis H. Philipson, Barton Wicksteed
forskolin at 2 μM (
Sigma–Aldrich
, cat. #
F6886
), and H89 at 20 μM (
Cell Signaling Technologies
, cat #
9844
). Cells were infected with
adenovirus
expressing an activated catalytic PKA subunit [27] or a mutated,
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H-89, Dihydrochloride from Cell Signaling Technology
Supplier Page
View Company Product Page
Pricing Info
Product Specs
Company Info
Citations
Reviews
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