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Protein Biochemistry
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U0126
U0126 from Cell Signaling Technology
Be the first to write a review!
Citations:
(250)
Supplier Page
Supplier Page from
Cell Signaling Technology for
U0126
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
U0126
Company
Cell Signaling Technology
Price
Pricing Info
Supplier Page
View Company Product Page
Catalog Number
9903S
Quantity
5 mg
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Cell Signaling Technology
3 Trask Lane
Danvers
,
Massachusetts
01923
United States
Phone
: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488
Company Profile
Website:
http://www.cellsignal.com/
Website:
Technical Support
Citations (250)
(1)
An engineered interleukin‐11 decoy cytokine inhibits receptor signaling and proliferation in lung adenocarcinoma
Bioengineering & Translational Medicine
November 1, 2023
Brianna J. McIntosh, Griffin G. Hartmann, Sean A. Yamada‐Hunter, Phillip Liu, Camille F. Williams, Julien Sage, Jennifer R. Cochran
cells per well. Cells were starved in serum‐free media for 2 h. For phospho‐
ERK
assays
, 10 μM
U0126
(
9903S
,
Cell Signaling Technology
) was added to reduce baseline signaling levels. For agonism
assays
, IL‐11
(2)
MAPK/ERK and PI3K/AKT signaling pathways are activated in adolescent and adult acute lymphoblastic leukemia
Cancer Rep (Hoboken)
October 22, 2023
Gustavo Loureiro, Daniella M. Bahia, Maria Lucia M. Lee, Mair Pedro de Souza, Eliza Y. S. Kimura, Denise Carvalho Rezende, Marçal Cavalcante de Andrade Silva, Maria de Lourdes L. F. Chauffaille, Mihoko Yamamoto
either untreated or treated with mitogen‐activated protein kinase kinase (MEKK)
inhibitor
,
U0126
10 mM (#
9903
,
Cell Signaling
, Beverly, MA, USA) working solution in methanol (#A411‐20, Fisher Scientific, Fair Lawn,
(3)
ERK1-mediated immunomodulation of mesenchymal stem cells ameliorates inflammatory disorders
iScience
October 20, 2023
Qing Zhang, Xiao Lei, Fang Wang, Xiaoning He, Lu Liu, Yuxia Hou, Yuan Liu, Fang Jin, Chider Chen, Bei Li
(CII),Chondrex,Cat # 20062 Licochalcone A,
Sigma
,Cat # PHL80486
U0126
,
Cell Signaling Technology
,Cat #
9903S
,, Critical commercial
assays
,Critical commercial
assays
,Critical commercial
assays
,,
PE Annexin V Apoptosis Detection Kit I
(4)
Heterogeneity in the Metastatic Microenvironment: JunB-Expressing Microglia Cells as Potential Drivers of Melanoma Brain Metastasis Progression
Cancers (Basel)
October 13, 2023
Orit Adir, Orit Sagi-Assif, Tsipi Meshel, Shlomit Ben-Menachem, Metsada Pasmanik-Chor, Dave S. B. Hoon, Isaac P. Witz, Sivan Izraely
Zhejiang, China),
SP600125
(20 µM,
S5567
,
Sigma-Aldrich
, St. Louis, MO, USA), and
U0126
(5 µM,
CST
-
9903S
, Cell Signaling Technology, Danvers, MA, USA). Lysates were prepared as previously described [20]. 2.14.
(5)
Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes
iScience
September 15, 2023
Prem Swaroop Yadav, Garyfallia Papaioannou, Margaret M. Kobelski, Marie B. Demay
PDGFR Tyrosine Kinase Inhibitor IV
,
Sigma
USA,Cat. #521233
U0126
,"
Cell Signaling Technologies
, Danvers, Massachusetts, USA,",Cat. #
9903
BCA
protein assay
,"Pierce,
Thermo Scientific
, USA",Cat. #
23223
Fluoroshield™ mounting media with DAPI,"Millipore
(6)
Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest
Life science alliance
August 1, 2023
Acharya BR, Fang JS, Jeffery ED, Chavkin NW, Genet G, Vasavada H, Nelson EA, Sheynkman GM, Humphries MJ, Hirschi KK.
μM for 1 h, or 2.5 μM for 12 h; Cat# 1130;
Tocris
),
U0126
(10 μM for 1 h, or 2.5 μM for 12 h; Cat#
9903
;
Cell Signaling Technology
), MK8353 (2.5 μM for 12 h; Cat# SCH900353; SelleckChem), nocodazole (10 μM
(7)
RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status
Oncogene
May 12, 2023
Coralie Dorard, Claire Madry, Olivier Buhard, Stefanie Toifl, Sebastian Didusch, Toky Ratovomanana, Quentin Letourneur, Helmut Dolznig, Mathew J. Garnett, Alex Duval,
et al.
treatment Spheroids and patient-derived
organoids
were treated with 1 µM or 10 µM
U0126
(
Cell signaling
#
9903
; concentrations stated in the figure legend) and/or 1 µM GW5074 (
MedChemExpress
#
HY-10542
), or with
(8)
25KDa branched polyethylenimine increases interferon-γ production in natural killer cells via improving translation efficiency
Cell Communication and Signaling
May 9, 2023
Eun-Su Ko, Seung Hee Choi, Minwook Lee, Kyung-Soon Park
Gibco/Life Technologies), Chem_NK cells were resuspended in NK cell culture medium. The MEK inhibitor U0126 (
9903S
,
Cell Signaling Technology
, Danvers, MA), the mTOR
inhibitor
rapamycin (37094, Sigma-Aldrich), the MNK
(9)
Ovulatory signal-triggered chromatin remodeling in ovarian granulosa cells by HDAC2 phosphorylation activation-mediated histone deacetylation
Epigenetics & Chromatin
April 19, 2023
Jiamin Jin, Peipei Ren, Xiang Li, Yinyi Zhang, Weijie Yang, Yerong Ma, Mengru Lai, Chao Yu, Songying Zhang, Yin-Li Zhang
USA), as described previously [34], for 30 min, 1 h, 2 h and 4 h. FK228 (100 nM) or
U0126
(10 µM; #
9903
,
CST
, USA) was added, and the GCs were incubated with these reagents for 12 h before FSK/PMA treatments.
(10)
HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation
eLife
March 24, 2023
Scinicariello S, Soderholm A, Schäfer M, Shulkina A, Schwartz I, Hacker K, Gogova R, Kalis R, Froussios K, Budroni V,
et al
.
μM,
Sigma-Aldrich
,PZ0188 "
U0126
, MEKi
inhibitor
",ERKi,
Cell culture
,250 nM,
Cell Signaling Technology
,
9903
Okadaic Acid,OA,
Cell culture
,1 μM,
Cell Signaling Technology
,
5934
Calyculin A
,CalycA,
Cell culture
,50
(11)
Inhibition of ERK/CREB signaling contributes to postoperative learning and memory dysfunction in neonatal rats
Journal of Molecular Medicine
March 1, 2023
Hui Wang, Gang Ma, Jia Min, Jun Li, Weiran Shan, Zhiyi Zuo
or GDNF Some
rats
received intracerebroventricular
injection
of 3 μl 10 mM
U0126
(catalogue number:
9903
;
Cell signaling Technology
, Danvers, MA) or 1.2 μg
rat
BNP (1–32) (catalogue number: RP11121; GenScript
(12)
Asparaginyl endopeptidase contributes to cetuximab resistance via MEK/ERK signaling in RAS wide-type metastatic colorectal cancer
Clinical and Translational Oncology
January 7, 2023
Xiaojing Xu, Mengling Liu, Ke Peng, Yiyi Yu, Tianshu Liu
pathways,
AEP
inhibitors
(AEPI, obtained from Lin [26]) or MEK
inhibitors
U0126
(
Cell Signaling Technology
,
9903
) were used for cell intervention. Cetuximab-resistant CRC cells establishment NCI-H508 cells, known
(13)
The lysophosphatidic acid-regulated signal transduction network in ovarian cancer cells and its role in actomyosin dynamics, cell migration and entosis
Theranostics
January 1, 2023
Ojasalu K, Lieber S, Sokol AM, Nist A, Stiewe T, Bullwinkel I, Finkernagel F, Reinartz S, Müller-Brüsselbach S, Grosse R,
et al
.
Chemicals (Ann Arbor, MI, USA); CRT0066101 (SML1507) from
Sigma-Aldrich
(Taufkirchen, Germany);
U0126
(
9903
) from
Cell Signaling
(Frankfurt, Germany). All
inhibitors
, their targets and the concentrations used
(14)
Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease
Communications Biology
December 1, 2022
Leon C. D. Smyth et al.
USA",CP-868596
CP-673451
,PDGFRβ,0.1,>2,"
Sigma
, MO, USA",
PZ0012
Wortmannin
,PI3K,0.1,>2,"
Cell Signalling
, MA, USA",
9903
U0126
,MEK/ERK,10,>2,"
Sigma
, MO, USA",
W1628
TPCA-1
,IκK,10,>2,"
Tocris
, UK",2559 Specifications for
(15)
Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis
EBioMedicine
December 1, 2022
Xu S, Yang X, Chen Q, Liu Z, Chen Y, Yao X, Xiao A, Tian J, Xie L, Zhou M,
et al
.
vehicle or
LIF
for indicated time period. The
inhibitors
used were as follows: ERK inhibitor UO126 (#
9903
,
Cell Signaling Technology
, Beverly, Massachusetts, USA),
STAT3
inhibitor
stattic (
s7024
,
Selleckchem
,
(16)
2'-5' oligoadenylate synthetase‑like 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability
Nature communications
November 4, 2022
Kim TK, Jeon S, Park S, Sonn SK, Seo S, Suh J, Jin J, Kweon HY, Kim S, Moon SH,
et al
.
inhibitor
,
LY294002
(
Cell Signaling Technology
,
9901
), MEK1/2 inhibitor,
U0126
(
Cell Signaling Technology
,
9903
), mTOR
inhibitor
, rapamycin (
Cell Signaling Technology
,
9904
), NF-κB
inhibitor
, Bay-11 (
Sigma
,
B5556
),
(17)
DHCR24 Knockdown Induces Tau Hyperphosphorylation at Thr181, Ser199, Ser262, and Ser396 Sites via Activation of the Lipid Raft-Dependent Ras/MEK/ERK Signaling Pathway in C8D1A Astrocytes
Molecular neurobiology
September 1, 2022
Mai M, Guo X, Huang Y, Zhang W, Xu Y, Zhang Y, Bai X, Wu J, Zu H.
Cell Signaling Technology
), Phospho-
MEK1
/2 (Ser217/221)(#
9154
,
Cell Signaling Technology
),
U0126
(#
9903
,
Cell Signaling Technology
),
Propidium Iodide
(abs9105, Absin),
Methyl-β-cyclodextrin
(abs42021762,
(18)
IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells
iScience
August 19, 2022
Widjaja AA, Viswanathan S, Wei Ting JG, Tan J, Shekeran SG, Carling D, Lim WW, Cook SA.
SuperSignal™ West Femto Maximum Sensitivity Substrate
,
Thermo Fisher Scientific
,Cat#
34096
U0126
,
Cell Signaling
,Cat#
9903
Recombinant HyperIL-11,"Genscript (Dams-Kozlowska et al., 2012)",N/A Recombinant human IL6,R&D Systems,Cat#
(19)
IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues
International Journal of Molecular Sciences
August 10, 2022
Anissa A. Widjaja, Sonia Chothani, Sivakumar Viswanathan, Joyce Wei Ting Goh, Wei-Wen Lim, Stuart A. Cook
agitation prior to use. 4.3. Chemicals Stattic (
S7947
,
Sigma-Aldrich
, St. Louis, MO, USA),
U0126
(
9903
,
CST
, Danvers, MA, USA). 4.4.
Cell Culture
Cells were grown and maintained at 37 °C and 5% CO2. Primary
(20)
Hepatocyte-secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARalpha/FGF21 axis
Cellular and Molecular Gastroenterology and Hepatology
August 2, 2022
Han Qiu, Erfei Song, Yue Hu, Tengfei Li, Kam Ching Ku, Cunchuan Wang, Bernard M.Y. Cheung, Lai Yee Cheong, Qin Wang, Xiaoping Wu,
et al.
lysophosphatidic acid (
62215
;
Cayman
, Ann Arbor, MI), fenofibrate (Abbott Laboratories, Chicago, IL),
U0126
(
9903
;
Cell Signaling Technology
), wortmannin (
W1628
;
Sigma
), PF8380 (
12018
;
Cayman
), and
Ki16425
(
10012659
;
Page
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Reviews
Be the First to Write a Review!
U0126 from Cell Signaling Technology
Supplier Page
View Company Product Page
Pricing Info
Product Specs
Company Info
Citations
Reviews
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