Description
A potent inhibitor of LDHA and LDHB (IC50s = 2.6 and 0.43 nM, for human recombinant LDHA and LDHB, respectively); inhibits lactate production in Snu398 hepatocellular carcinoma cells in which LDHB expression is undetectable (EC50 = 400 nM); reduces glucose consumption in Snu398 but not HepG2 cells; 30 cancer cell lines show differential sensitivities to GSK2837808A (EC50s from 400 nM to 30 µM); potency does not correlate with LDHA, LDHB, or total LDH expression levels