Fingolimod (hydrochloride) from Cayman Chemical

Product Specs
ItemFingolimod (hydrochloride)
CompanyCayman Chemical
Price Pricing Info Supplier Page View Company Product Page
Catalog Number10006292
FormatA crystalline solid
Research AreaAdaptive Immunity, Glycerophospholipids, Immunology & Inflammation, Innate Immunity, Lipid Biochemistry, Lipid Transport, Multiple Sclerosis, Neurodegenerative Disorders, Neuroscience, Phospholipases, Sphingolipids
Molecular Weight343.9
Quantity1 g
Purity≥98%

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effectsJournal of General PhysiologyJanuary 1, 2024Gregory W. Busey, Mohan C. Manjegowda, Tao Huang, Wesley H. Iobst, Shardul S. Naphade, Joel A. Kennedy, Catherine A. Doyle, Philip V. Seegren, Kevin R. Lynch, Bimal N. DesaiVirginia). FTY720 (fingolimod), L-threo-sphingosine, and NS8593 were purchased from Cayman Chemical (item #10006292, #10010541, and #29774, respectively). AAL-149 was solubilized in 100% ethanol, and all other compounds

(2) Expansion of circulating stem-like CD8(+) T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in miceNature communicationsApril 12, 2023Onyshchenko K, Luo R, Guffart E, Gaedicke S, Grosu AL, Firat E, Niedermann G.injected. To block T cell egress from lymph nodes, FTY720 (25 μg per mouse Fingolimod, Cayman Chemical, 10006292) was i.p. injected 1 day before treatment start and then every other day to maintain the blockade. CD8+

(3) Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasisCell reportsDecember 6, 2022Janneh AH, Kassir MF, Atilgan FC, Lee HG, Sheridan M, Oleinik N, Szulc Z, Voelkel-Johnson C, Nguyen H, Li H, et al.Chemicals,Cat# 10009458 PF-543,Cayman Chemicals,Cat# 17034 Fingolimod (hydrochloride),Cayman Chemicals,Cat# 10006292 ABC294640,Cayman Chemicals,Cat# 10587 "Corning® Fibronectin, Human, 1 mg",Corning Inc.,Cat# 354008 Cathepsin-L

(4) Pharmacological Targeting of Sphingosine Kinases Impedes HIV-1 Infection of CD4 T Cells through SAMHD1 ModulationJournal of VirologyMay 11, 2022Rachel S. Resop, Alberto Bosque(fingolimod/gilenya), DMS, SKI II, and ABC294640 were obtained from Cayman Chemical (FTY720, number 10006292, CAS number 162359-56-0; DMS, number 62575, CAS number 119567-63-4; SKI II, number 10009222, CAS number

(5) Clonotypic analysis of protective influenza M2e-specific lung resident Th17 memory cells reveals extensive functional diversityMucosal ImmunologyApril 1, 2022Ajibola Omokanye, Li Ching Ong, Cristina Lebrero-Fernandez, Valentina Bernasconi, Karin Schön, Anneli Strömberg, Mats Bemark, Xavier Saelens, Paulo Czarnewski, Nils Lyckeblock lymphocyte egress from secondary lymphnodes and spleen mice were given 100 µg FTY720 (Cayman 10006292-50) i.p. in 200 μL sterile PBS every 48 h during the experiment. For testing of Trm status of the M2e-tetramer

(6) Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammationImmunityFebruary 8, 2022Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, et al.,R&D systems,Cat#3626-ML-010/CF Recombinant mouse IFNg,R&D systems,Cat#485-MI-100/CF FTY720,Cayman Chemicals,Cat#10006292 W146,TOCRIS,Cat#3602 Batch N.2 CYM50358 hydroxichloride,TOCRIS,Cat#4679 "1X Hanks’ Balanced Salt

(7) Characterization of CD41(+) cells in the lymph nodeFrontiers in immunologyJanuary 1, 2022Dai L, Uehara M, Li X, LaBarre BA, Banouni N, Ichimura T, Lee-Sundlov MM, Kasinath V, Sullivan JA, Ni H, et al.to assess their differentiation and function. Methods Reagents FTY720 (Cayman Chemical Company, 10006292) was purchased from Cayman, Ann Arbor, Michigan, USA. Methylcellulose-based medium (STEMCELL, MethoCult™ GF M3434

(8) PTX Instructs the Development of Lung-Resident Memory T Cells in Bordetella pertussis Infected MiceToxins (Basel)September 8, 2021Julie Tomas, Yoon Koo, Dimitri Popoff, Vilma Arce-Gorvel, Sean Hanniffy, Jean-Pierre Gorvel, Cyrille Mionnetthe same method than previously described. 4.4. Fingolimod Treatment For FTY720 experiment (item n°10006292, Cayman Chemical Company, Ann Arbor, MI, USA), mice were treated with 8 mg/mL of FTY720 in drinking

(9) Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loopCellJuly 22, 2021Marangoni F, Zhakyp A, Corsini M, Geels SN, Carrizosa E, Thelen M, Mani V, Prüßmann JN, Warner RD, Ozga AJ, et al.proteins" CD80-Fc chimera,BioLegend,Cat# 555404 CD86-Fc chimera,BioLegend,Cat#771704 FTY720,Cayman,Cat# 10006292 Diphtheria Toxin,Calbiochem,Cat# 32232619/07/ Tamoxifen,Sigma,Cat# T5648 Brefeldin A,Biolegend,Cat

(10) SPNS2 enables T cell egress from lymph nodes during an immune responseCell reportsJuly 13, 2021Okuniewska M, Fang V, Baeyens A, Raghavan V, Lee JY, Littman DR, Schwab SR.A2512 "Adjuvant, Incomplete (Freund)",BD Difco,Cat# BD 263910 Fingolimod (FTY720),Cayman Chemical,Cat# 10006292 MOG 35–55 peptide,Genscript,Cat# RP10245 Pertussis toxin,List Biological Laboratories,Cat# 181 Tamoxifen,SigmaAldrich,Cat#

(11) Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cellsThe Journal of clinical investigationApril 1, 2021Liikanen I, Lauhan C, Quon S, Omilusik K, Phan AT, Bartrolí LB, Ferry A, Goulding J, Chen J, Scott-Browne JP, et al.flank. For tissue-resident memory protection experiments, 1 mg/kg per mouse of FTY720 (Cayman Chemical, 10006292) or vehicle control was i.p. injected daily, starting 3 days before tumor rechallenge with 4.5 × 105

(12) Plasma cell dynamics in the bone marrow nicheCell reportsFebruary 9, 2021Benet Z, Jing Z, Fooksman DR.AM9261 "Fibronectin, Bovine Plasma",Sigma-Aldrich,Cat# 341631-1MG Fingolimod (FTY720),Cayman Chemical,Cat# 10006292 GIBCO Fetal Bovine Serum,Thermo Fisher Scientific,Cat# 10-437-028 Imject Alum Adjuvant,Thermo Fisher Scientific

(13) Sphingosine-1-Phosphate Receptor 3 Potentiates Inflammatory Programs in Normal and Leukemia Stem Cells to Promote DifferentiationBlood Cancer DiscoveryJanuary 18, 2021Stephanie Z. Xie et al.characteristics in Supplemental Table 10). Vehicle control (DMSO) or 1mg/kg FTY720 (Cayman Chemicals, 10006292, assuming average weight for NSG mouse to be 25 g) was diluted in PBS and administered to mice by intraperitoneal injections

(14) Fingolimod inhibits multiple stages of the HIV-1 life cyclePLOS PathogensAugust 13, 2020Rachel S. Resop, Rémi Fromentin, Daniel Newman, Hawley Rigsby, Larisa Dubrovsky, Michael Bukrinsky, Nicolas Chomont, Alberto Bosquedye, CXCR4PE-Cy5.5, CCR5-AF488). FTY720 (Fingolimod) was obtained from Cayman Chemical (MI, cat. # 10006292, CAS#162359-56-0). Cell culture and generation of primary cell model of latency Human peripheral blood

(15) Dendritic Cell Maturation Defines Immunological Responsiveness of Tumors to Radiation TherapyThe Journal of ImmunologyJune 15, 2020Tiffany C. Blair et al.again 7 days later. To block T cell egress during treatment, FTY720 from Cayman Chemical Company (#10006292) was administered at 1 mg/kg/day intraperitoneally, starting 1 day prior to radiation for a total of

(16) Targeting Lymph Node Niches Enhances Type 1 Immune Responses to ImmunizationCell reportsMay 26, 2020Lian J, Ozga AJ, Sokol CL, Luster AD.5401054001 Lipopolysaccharide,InvivoGen,Cat# tlrl-eklps FTY720 (Fingolimod),Cayman Chemicals,Cat# 10006292 Diphtheria Toxin from Corynebacterium diphtheriae,Sigma-Aldrich,Cat# D0564-1 MG OCT Compound,Tissue-Tek,Cat#

(17) FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemiaCell death & diseaseNovember 7, 2019Young MM, Bui V, Chen C, Wang HG.MycoAlert Mycoplasma detection kit (Lonza, Basel, Switzerland, #LT07-318). Chemicals and reagents FTY720 (dissolved in DMSO; #10006292), FTY720-phosphate (dissolved in DMSO; #10008639), NBD-FTY720 (dissolved in DMSO; #16841), calyculin A

(18) The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8⁺ T Cell Fitness and FunctionalityImmunitySeptember 17, 2019Li C, Zhu B, Son YM, Wang Z, Jiang L, Xiang M, Ye Z, Beckermann KE, Wu Y, Jenkins JW, et al.21-040-CV On-Column DNase I Digestion Set,Sigma-Aldrich,Cat# DNASE70 FTY720,Cayman Chemical,Cat# 10006292 Corning™ Cell-Tak Cell and Tissue Adhesive,Corning™,Cat# CB40240 "Monensin Solution (1,000X)",BioLegend,Cat#

(19) The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 CellsImmunityJuly 16, 2019Omenetti S, Bussi C, Metidji A, Iseppon A, Lee S, Tolaini M, Li Y, Kelly G, Chakravarty P, Shoaie S, et al.5.5,ThermoFisher,cat#AM9740 Bovine serum albumin (BSA),New England BioLabs,cat#B90005 FTY720,Cayman Chemical,cat#10006292 Dimethyl sulfoxide (DMSO),Sigma-Aldrich,cat#D2650 Emulsion containing MOG35–55 and killed Mycobacterium tuberculosis

(20) Role of the S1P pathway and inhibition by fingolimod in preventing hemorrhagic transformation after strokeScientific reportsJune 5, 2019Salas-Perdomo A, Miró-Mur F, Gallizioli M, Brait VH, Justicia C, Meissner A, Urra X, Chamorro A, Planas AM.treatment (A/B) to each mouse, and treatment was administered in a blinded fashion. Fingolimod (1 mg/kg) (#10006292, Cayman Chemical, Ann Arbor, MI, USA) or the vehicle (saline containing 0.5% DMSO) was administered

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Fingolimod (hydrochloride) from Cayman Chemical

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Cayman Chemical

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Fingolimod (hydrochloride) from Cayman Chemical

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