Description
A Na+/K+-ATPase inhibitor; induces loss of the transmembrane Na+ gradient, which decreases activity of the Na+/Ca2+ exchanger, increasing intracellular Ca2+ levels, inotropy, and cardiac force; increases activity of mitochondrial ATPase and actomyosin ATPase in rat hearts, which is directly correlated with increased myofibrillar contractile strength; decreases right atrial pressure and increases cardiac output in a canine model of congestive heart failure produced by pulmonary artery constriction