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Protein Biochemistry
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UNC1999
UNC1999 from Cayman Chemical
Be the first to write a review!
Citations:
(6)
Supplier Page
Supplier Page from
Cayman Chemical for
UNC1999
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Description
A selective, cell-permeable EZH2 inhibitor (IC50 = 2 nM) that has been shown to inhibit H3K27methylation in MCF10A cells with an IC50 value of 124 nM
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
UNC1999
Company
Cayman Chemical
Price
Pricing Info
Supplier Page
View Company Product Page
Catalog Number
14621
Format
A crystalline solid
Research Area
Epigenetics, Transcription, & Translation, Histone Methylation, Writers
Molecular Weight
569.8
Quantity
10 mg
Purity
≥98%
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Cayman Chemical
Cayman Chemical Company 1180 East Ellsworth Road
Ann Arbor
,
Michigan
48108
United States
Phone
: (800) 364-9897
(734) 971-3640
Company Profile
Website:
http://www.caymanchem.com/
Citations (6)
(1)
Epigenetic dynamics during capacitation of naïve human pluripotent stem cells
Science Advances
September 29, 2023
João Agostinho de Sousa, Chee-Wai Wong, Ilona Dunkel, Thomas Owens, Philipp Voigt, Adam Hodgson, Duncan Baker, Edda G. Schulz, Wolf Reik, Austin Smith,
et al.
passaging. (68). PCR2 inhibition Cell permeable EZH2
inhibitor
UNC1999
(
Cayman Chemical
, catalog no.
14621
) was used at concentrations 1, 1.75, or 2.5 μM. Short-term inhibition was done for 4 days. and long-term
(2)
Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells
Frontiers in Cell and Developmental Biology
March 23, 2023
Y. Sbirkov, T. Schenk, C. Kwok, S. Stengel, R. Brown, G. Brown, L. Chesler, A. Zelent, M. J. Fuchter, K. Petrie
Sigma-Aldrich
); GSK-343 (Cat#
14094
,
Cayman Chemical
); BIX-01294 (Cat#
13124
,
Cayman Chemical
);
UNC1999
(Cat#
14621
,
Cayman Chemical
) and
Dimethyl sulfoxide (DMSO
, Cat#
D8418
,
Sigma-Aldrich
). HKMTI-1-005 was provided
(3)
Response and resistance to CDK12 inhibition in aggressive B-cell lymphomas
Haematologica
May 1, 2022
Jing Gao et al.
17017
),
UNC0642
(
Cayman Chemical
,
14604
),
UNC1215
(
Cayman Chemical
, 1398),
UNC1999
(
Cayman Chemical
,
14621
). Agents were dissolved in DMSO to a final concentration of 10 mM, aliquoted, and then stored at –20°C. Methods Generation
(4)
NFAT5 Amplifies Antipathogen Responses by Enhancing Chromatin Accessibility, H3K27 Demethylation, and Transcription Factor Recruitment
Journal of immunology (Baltimore, Md. : 1950)
June 1, 2021
Lunazzi G, Buxadé M, Riera-Borrull M, Higuera L, Bonnin S, Huerga Encabo H, Gaggero S, Reyes-Garau D, Company C, Cozzuto L,
et al
.
GSK-J4 (hydrochloride
) was from Tocris Bioscience (4594) or from
Cayman Chemical
(
12073
). GSK-126 (
15415
) and
UNC1999
(
14621
) were from
Cayman Chemical
. These
inhibitors
were used at 10 mM. Pretreatment with GSK-J4 was for 1
(5)
Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma
Cell reports
March 16, 2021
Zhao X, Wang MY, Jiang H, Lwin T, Park PM, Gao J, Meads MB, Ren Y, Li T, Sun J,
et al
.
S2673
UNC0642
,
Cayman Chemical
,Item#
14604
UNC1215
,
Cayman Chemical
,Item#
13968
UNC1999
,
Cayman Chemical
,Item#
14621
VE-821
,
Selleckchem
,Cat#
S8007
Volasertib,
Selleckchem
,Cat#
S2235
Critical commercial
assays
,Critical
(6)
BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models
Cancer cell
May 13, 2019
Zhao X, Ren Y, Lawlor M, Shah BD, Park PMC, Lwin T, Wang X, Liu K, Wang M, Gao J,
et al
.
S1555
MK-2206,
Selleckchem
,Cat#
S1078
MK-1775
,
Selleckchem
,Cat#
S1525
UNC1999
,
Cayman Chemical
,Cat#
14621
Alisertib,
Selleckchem
,Cat#
S1133
BEZ-235,
Selleckchem
,Cat#
S1009
AZD7762
,
Selleckchem
,Cat#
S1532
INCB053914,"Incyte
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UNC1999 from Cayman Chemical
Supplier Page
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