SARS-CoV Spike S1+S2 ECD-His Recombinant Protein (S577A, Isolate Tor2) 40634-V08B from Sino Biological, Inc.

Product Specs
ItemSARS-CoV Spike S1+S2 ECD-His Recombinant Protein (S577A, Isolate Tor2)
CompanySino Biological, Inc.
Price Supplier Page View Company Product Page
Catalog Number40634-V08B
TypeRecombinant protein
Molecule NameSpike
SpeciesSARS
FormatLyophilized from sterile 20mM PB, 300mM NaCl, pH 7.0, 10% glycerol
Conjugate/TagC-His
Source/Expression SystemBaculovirus-Insect Cells
Molecular WeightThe recombinant SARS-CoV (isolate: Tor2) spike S1+S2 ECD consists of 1193 amino acids and predicts a molecular mass of 132.58 kDa
Purity> 90 % as determined by SDS-PAGE
ActivityMeasured by its binding ability in a functional ELISA. Immobilized ACE2 Protein, Human, Recombinant (mFc Tag)(10108-H05H) at 2µg/mL (100µL/well) can bind SARS-CoV Spike S1+S2 ECD-His Recombinant Protein (S577A, Isolate Tor2)(40634-V08B),the EC50 of SARS-CoV Spike S1+S2 ECD-His Recombinant Protein (S577A, Isolate Tor2)(40634-V08B) is 300-900ng/mL
NCBI Gene AliasesE2

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Sino Biological, Inc.

1400 Liberty Ridge Drive

Suite 101

Wayne, PA 19087

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: http://www.sinobiological.com/

(1) Fc-mediated pan-sarbecovirus protection after alphavirus vector vaccinationCell reportsApril 25, 2023Adams LE, Leist SR, Dinnon KH 3rd, West A, Gully KL, Anderson EJ, Loome JF, Madden EA, Powers JM, Schäfer A, et al.,Sino Biological,10202-V08H1 Human Coronavirus 229E Spike,Sino Biological,40605-V08B SARS-CoV-1 Spike,Sino Biological,40634-V08B PE-Streptavidin,Agilent Technologies,PB32-10 Guinea Pig Complement,Cedarlane,CL4051 Protein Transport

(2) Broad and durable antibody response after vaccination with inactivated SARS-CoV-2 in individuals with a history of 2003 SARS-CoV infectionEmerging Microbes & InfectionsDecember 31, 2022Huang Liang et al.SARS-CoV-2, and S2 protein of SARS-CoV-2 (Sinobiological, Beijing, SARS-CoV N Cat:40143-V08B, SARS-CoV S Cat:40634-V08B, SARS-CoV RBD Cat:40150-V08B2, SARS-CoV-2 N Cat:40588-V08B, SARS-CoV-2 S Cat:40589-V08B1, SARSCoV-2

(3) SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinationsCell reportsOctober 18, 2022Anderson EM, Li SH, Awofolaju M, Eilola T, Goodwin E, Bolton MJ, Gouma S, Manzoni TB, Hicks P, Goel RR, et al.S2, and 229E FL-S were purchased (Sino Biological, Wayne PA; cat. 40606-V08B, 40021-V08H, 40021-V08B, 40634-V08B, 40150-V08B1, 40150-V08B3, and 40605-V08B, respectively). ELISAs Antibodies reactive to SARS-CoV-2,

(4) A key F27I substitution within HCDR1 facilitates the rapid maturation of P2C-1F11-like neutralizing antibodies in a SARS-CoV-2-infected donorCell ReportsSeptember 13, 2022Miao Wang, Qing Fan, Bing Zhou, Haocheng Ye, Senlin Shen, Jiazhen Yu, Lin Cheng, Xiangyang Ge, Bin Ju, Zheng Zhang40589-V08B1 SARS-CoV-2 WT NP,Sino Biological Inc.,Cat# 40588-V08B SARS-CoV spike,Sino Biological Inc.,Cat# 40634-V08B MERS-CoV spike,Sino Biological Inc.,Cat# 40069-V08B HCoV-HKU1 spike,Sino Biological Inc.,Cat# 40606-V08B HCoV-OC43

(5) Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster modelsCommunications biologySeptember 9, 2022Rossotti MA, van Faassen H, Tran AT, Sheff J, Sandhu JK, Duque D, Hewitt M, Wen X, Bavananthasivam J, Beitari S, et al.Cytiva). On the first sensor chip, 1983 response units (RUs) of SARS-CoV spike (SinoBiological, Cat#40634-V08B), 843 RUs of SARS-CoV-2 RBD/SD1 fused to human Fc (RBD/SD1-Fc) and 972 RUs of EGFR (Genscript, Cat#

(6) Multiplexed LNP-mRNA vaccination against pathogenic coronavirus speciesCell ReportsAugust 2, 2022Lei Peng et al.Delta variant B.1.617.2 (SINO, ECD 40589-V08B16 and RBD 40592-V08H90), SARS-CoV (ECD Sino Biological 40634-V08B and RBD Fisher 50-196-4017) and MERS-CoV (ECD Sino Biological and RBD Fisher 50-201-9463). Plates were

(7) Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2Nature microbiologyJuly 1, 2022Sun X, Yi C, Zhu Y, Ding L, Xia S, Chen X, Liu M, Gu C, Lu X, Fu Y, et al.

(8) Glycopeptide Antibiotic Teicoplanin Inhibits Cell Entry of SARS-CoV-2 by Suppressing the Proteolytic Activity of Cathepsin LFrontiers in MicrobiologyApril 28, 2022Fei Yu et al.S1399, United States). After activation, about 2 μg in vitro purified SARS-CoV S (Sino Biological Inc., 40634-V08B, China) or SARS-CoV-2 S (Sino Biological Inc., 40589-V08B1, China) were added into each group. S protein

(9) Neutralizing Monoclonal Antibodies Inhibit SARS-CoV-2 Infection through Blocking Membrane FusionMicrobiology spectrumApril 27, 2022Li CJ, Chao TL, Chang TY, Hsiao CC, Lu DC, Chiang YW, Lai GC, Tsai YM, Fang JT, Ieong S, et al.100 ng of NTD, RBD, S2, and S proteins of SARS-CoV-2, SARS-CoV (Sino Biological Inc., Catalog Number: 40634-V08B) or MERS-CoV (Sino Biological Inc., Catalog Number: 40069-V08B) were blocked with 0.25% gelatin in PBS

(10) Neutralization or enhancement of SARS-CoV-2 infection by a monoclonal antibody targeting a specific epitope in the spike receptor-binding domainAntiviral researchApril 1, 2022Lai GC, Chao TL, Lin SY, Kao HC, Tsai YM, Lu DC, Chiang YW, Chang SY, Chang SC.pre-coated with 100 ng of S protein of SARS-CoV-2, SARS-CoV (Sino Biological Inc., Catalog Number: 40634-V08B), or MERS-CoV (Sino Biological Inc., Catalog Number: 40069-V08B) were blocked with 0.25% gelatin in

(11) Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individualsThe Journal of allergy and clinical immunologyApril 1, 2022Li M, Liu J, Lu R, Zhang Y, Du M, Xing M, Wu Z, Kong X, Zhu Y, Zhou X, et al.spike protein (Sino Biological, 40589-V08B1, 100 ng per well), SARS-CoV spike protein (Sino Biological, 40634-V08B, 100 ng per well), or MERS-CoV spike protein (Sino Biological, 40069-V08B, 50 ng per well) overnight

(12) Boosting of cross-reactive antibodies to endemic coronaviruses by SARS-CoV-2 infection but not vaccination with stabilized spikeeLifeMarch 15, 2022Andrew R Crowley et al.by Jason McLellan,,Produced in Expi 293 "Peptide, recombinant protein",SARS-CoV-1 S,Sino Biological,40634-V08B, "Peptide, recombinant protein",SARS-CoV-1 S1,Sino Biological,40150-V08B1, "Peptide, recombinant protein",MERS

(13) Methods to Measure Antibody Neutralization of Live Human Coronavirus OC43VirusesOctober 14, 2021Boonyaratanakornkit J, Sholukh AM, Gray M, Bossard EL, Ford ES, Corbett KS, Corey L, Taylor JJ.at −20 °C. Recombinant spike for NL63 (cat#40604-V08B), 229E (cat#40605-V08B), and SARS-CoV-1 (cat#40634-V08B) were obtained from Sino Biological. 2.7. Tetramerization of Antigens Purified OC43 S2P and HPIV1

(14) Memory B cell repertoire for recognition of evolving SARS-CoV-2 spikeCellSeptember 16, 2021Tong P, Gautam A, Windsor IW, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Storm N, Malsick LE, et al.Schmidt,N/A HKU1 RBD,Obtained from the lab of Dr. Aaron Schmidt,N/A SARS-CoV S,Sino Biological,Cat# 40634-V08B MERS S,Sino Biological,Cat# 40069-V08B HKU1 S,Sino Biological,Cat# 40606-V08B OC43 S,Sino Biological,Cat#

(15) Comparative analysis of antibodies to SARS-CoV-2 between asymptomatic and convalescent patientsiScienceJune 25, 2021Connor J. Dwyer, Colleen A. Cloud, Cindy Wang, Philip Heidt, Paramita Chakraborty, Tara F. Duke, Shannon McGue, Braxton Jeffcoat, Jaclyn Dunne, Logan Johnson, et al.46438 MERS-CoV Spike protein,Sino Biological,Cat# 40069-V08B SARS-CoV Spike protein,Sino Biological,Cat# 40634-V08B hCoV-HKU1 Spike protein,Sino Biological,Cat# 40606-V08B hCoV-OC43 Spike protein,Sino Biological,Cat#

(16) Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2Science (New York, N.Y.)June 18, 2021Low JS, Vaqueirinho D, Mele F, Foglierini M, Jerak J, Perotti M, Jarrossay D, Jovic S, Perez L, Cacciatore R, et al.

(17) Surface Proteins of SARS-CoV-2 Drive Airway Epithelial Cells to Induce IFN-Dependent InflammationThe Journal of ImmunologyJune 15, 2021Gautam Anand, Alexandra M. Perry, Celeste L. Cummings, Emma St. Raymond, Regina A. Clemens, Ashley L. Steedwells and incubated with SARSCoV-2 S, E-Trunc, N protein (40588-V08B; Sino Biological), SARS-CoV-1 S (40634-V08B; Sino Biological), or MERS S (40069-V08B; Sino Biological) at 2 mg/ml or equal volume of water as control. Reactive

(18) Small-Molecule Inhibitors of the Coronavirus Spike: ACE2 Protein-Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2ACS infectious diseasesJune 11, 2021Bojadzic D, Alcazar O, Chen J, Chuang ST, Condor Capcha JM, Shehadeh LA, Buchwald P.S1–S6). Binding Assays SARS-CoV-2 S1 and RBD (cat. no. 40591-V08H and 40592-V08H), SARS-CoV S1+S2 (cat. no. 40634-V08B), HCoV-NL63 S1 (cat. no. 40600-V08H; all with His tag), and ACE2-Fc (cat. no. 10108-H05H) used in the

(19) Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug developmentSignal transduction and targeted therapyMarch 27, 2021Zhao MM, Yang WL, Yang FY, Zhang L, Huang WJ, Hou W, Fan CF, Jin RH, Feng YM, Wang YC, et al.Sino Biological, Cat. No. 40589-V08B1) and SARS-CoV S protein (NP_828851.1. Sino Biological, Cat. No. 40634-V08B) were purchased from Sino Biological (China). One microgram of each protein was incubated with 2 or

(20) Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entryPLoS pathogensMarch 1, 2021Ren W, Zhu Y, Wang Y, Shi H, Yu Y, Hu G, Feng F, Zhao X, Lan J, Wu J, et al.full-length spike protein of SARS-CoV-2 (SinoBiological, 40589-V08B1) or SARS-CoV (SinoBiological, 40634-V08B) C-terminally fused with His tag, and then stained with Anti-HIS-PE (Miltenyi Biotec#130-120-787). Values

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SARS-CoV Spike S1+S2 ECD-His Recombinant Protein (S577A, Isolate Tor2)

SARS-CoV Spike S1+S2 ECD-His Recombinant Protein (S577A, Isolate Tor2) from Sino Biological, Inc.

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Sino Biological, Inc.

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SARS-CoV Spike S1+S2 ECD-His Recombinant Protein (S577A, Isolate Tor2) from Sino Biological, Inc.

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