Human Siglec-2 / CD22 Protein (ECD,His Tag) 11958-H08H from Sino Biological, Inc.

Product Specs
ItemHuman Siglec-2 / CD22 Protein (ECD,His Tag)
CompanySino Biological, Inc.
Price $298.00Supplier Page View Company Product Page
Catalog Number11958-H08H
Conjugate/TagC-His
Purity≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe recombinant human CD22 consists of 679 amino acids and predictes a molecular mass of 76.6 kDa. As a result of glycosylation, it migrates as an approximately 108 kDa band in SDS-PAGE under reducing conditions
SpeciesHuman
Molecule NameCD22
Source/Expression SystemHEK293 Cells
FormatLyophilized from sterile PBS, pH 7.4
NCBI Full Gene NameCD22 molecule
NCBI Gene AliasesSIGLEC-2, SIGLEC2
Activity1.Immobilized Recombinant Human Siglec-2 / CD22 Protein (ECD,His Tag) (Cat: 11958-H08H) at 2 µg/mL (100 µL/well) can bind Anti-CD22 Antibody, the EC50 is 1.2-3.6 ng/mL (QC tested). 2.293 cells were transduced with anti-CD22-scFv and subjected to flow cytometric analysis using recombinant human CD22 protein (His tag) (left, Cat. No. 11958-H08H, red) and a negative control protein (blue). The cells were then stained with a PE-conjugated anti-His antibody. Non-transduced 293 cells were used as a control (right)(Routinely tested). 3.Loaded anti-CD22 antibody on ProA Biosensor, can bind Recombinant Human Siglec-2/CD22 Protein, His Tag (Cat. No. 11958-H08H) with an affinity constant of 1.55 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested)
Size100 µg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) CD22 modulation alleviates amyloid β-induced neuroinflammationJournal of neuroinflammationFebruary 5, 2025Mai YD, Zhang Q, Fung CL, Leung SO, Chong CH.(Sino Biological, 10015-HNAH), Geltrex (Gibco, A14133-02), human CD22 ECD (CD22 FL) (Sino Biological, 11958-H08H), human CD22 a.a. 176–687 (CD22 δ1) (Sino Biological, 11958-H08H1), mouse CD22 ECD (Sino Biological,

(2) CD19/CD22 bispecific chimeric antigen receptor‑NK‑92 cells are developed and evaluatedOncology lettersJune 1, 2023Kim H, Han M, Kim M, Kim H, Im HJ, Kim N, Koh KN.enzyme immunoassay. The microtiter plates were coated with 100 ng/well human CD22-His protein (cat. No. 11958-H08H, Sino Biological, Inc.) and incubated at 4°C overnight. After blocking with 3% bovine serum albumin

(3) Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cellNature medicineOctober 1, 2018Ruella M, Xu J, Barrett DM, Fraietta JA, Reich TJ, Ambrose DE, Klichinsky M, Shestova O, Patel PR, Kulikovskaya I, et al.in flow cytometry assays. Detection of CAR22 was performed using CD22-Fc/His (Sino Biologicals no. 11958-H08H) and anti-His-APC (R&D no. IC050A) or phycoerythrin (PE; AbCam no. ab72467) or CD22 protein conjugated

(4) Chimeric antigen receptors that trigger phagocytosiseLifeJune 4, 2018Morrissey MA, Williamson AP, Steinbach AM, Roberts EW, Kern N, Headley MB, Vale RD.

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Human Siglec-2 / CD22 Protein (ECD,His Tag)

Human Siglec-2 / CD22 Protein (ECD,His Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

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Human Siglec-2 / CD22 Protein (ECD,His Tag) from Sino Biological, Inc.

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