Fig 2: Representative photographs of WT and Apoe−/− mice with a dissecting AAA after EPO injection(A) A WT mouse had bilateral lower limbs paralysis.(B) The mouse (A) developed a dissecting AAA (indicated by the dashed frame).(C) A WT mouse developed massive intra-abdominal hemorrhage.(D) A WT mouse suffered from a large abdominal aortic hematoma (indicated by the dashed frame).(E) An Apoe−/− mouse had bilateral lower limbs paralysis.(F) The mouse (E) developed a dissecting AAA (indicated by the dashed frame).(G) An Apoe−/− mouse developed massive intra-abdominal hemorrhage.(H) An Apoe−/− mouse suffered from a large abdominal aortic hematoma (indicated by the dashed frame).

Fig 3: Representative H&E and Verhoeff staining of the abdominal aortic sections in WT and Apoe-/- mice receiving vehicle, low-, medium-, and high-dose of EPO treatment, respectivelyH&E (scale bars, 200 µm) and Verhoeff (scale bars, 100 µm) magnifications are shown.

Fig 4: Inject EPO solution into the peritoneal cavity of mice