BMPR-IA/ALK-3 Fc Chimera Protein 315-BR-100/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemBMPR-IA/ALK-3 Fc Chimera Protein
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog Number315-BR-100/CF
SpeciesHuman
FormatLyophilized from a 0.2 µm filtered solution in PBS
Quantity100 ug
Molecule NameBMPR-IA/ALK-3
NCBI Full Gene Namebone morphogenetic protein receptor type 1A
NCBI Gene Aliases10q23del, ACVRLK3, ALK-3, ALK3, BMPR-1A, CD292, SKR5
Purity>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 55 kDa, reducing conditions
Theoretical: 41.5 kDa (monomer)
Brand/TrademarkR&D Systems, a Bio-Techne Brand
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human BMPR-IA/ALK-3 Fc Chimera Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Available conjugates: Unconjugated

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(1) BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiationJournal of cell scienceAugust 21, 2020Mang T, Kleinschmidt-Doerr K, Ploeger F, Schoenemann A, Lindemann S, Gigout A.

(4) The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and HomeostasisPloS oneJanuary 1, 2015Martínez VG, Sacedón R, Hidalgo L, Valencia J, Fernández-Sevilla LM, Hernández-López C, Vicente A, Varas A.

(5) Primitive CML cell expansion relies on abnormal levels of BMPs provided by the niche and on BMPRIb overexpressionBloodNovember 28, 2013Laperrousaz B, Jeanpierre S, Sagorny K, Voeltzel T, Ramas S, Kaniewski B, Ffrench M, Salesse S, Nicolini FE, Maguer-Satta V.

(6) Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growthThe Journal of biological chemistryAugust 26, 2011Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, et al.

(7) Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammationBloodMay 5, 2011Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, Lai CS, Rauwerdink KM, Winn JC, Saez B, Cook CM, et al.

(8) BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signalingBloodOctober 15, 2008Jeanpierre S, Nicolini FE, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, Maguer-Satta V.

(9) A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7Journal of molecular biologySeptember 12, 2008Sengle G, Ono RN, Lyons KM, Bächinger HP, Sakai LY.

(12) Specification of dorsal telencephalic character by sequential Wnt and FGF signalingNature neuroscienceJuly 1, 2003Gunhaga L, Marklund M, Sjödal M, Hsieh JC, Jessell TM, Edlund T.

BMPR-IA/ALK-3 Fc Chimera Protein from R&D Systems, a Bio-Techne Brand