Fig 1: The logical model of psoriatic keratinocytesThe psoKC model represents (i) the cell fate decisions of keratinocytes (i.e. proliferation, apoptosis, differentiation) in response to IFNγ, TNFα (mainly produced by Th1 cells), IL-17, IL-22 (mainly produced by Th17 cells), and PGE2 and (ii) the influence of keratinocytes on the psoriatic environment by characterizing the secreted ligands (e.g. chemokines and cytokines), which would be produced by KCs and influence immune cells by sustaining their populations and inflammation. The node color depicts their functional role, the phenotype they promote, or the immune cell types they act on. Green lines represent activating interactions, and red lines represent inhibitory interactions.