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Publish or Perish: Calbiochem® Inhibitors
from EMD Millipore

PERK Inhibitor II results in high anti-tumor efficacy in mice.

PERK Inhibitor II (GSK2656157, Cat. No. 504651) is a cell-permeable, highly potent, ATP-competitive inhibitor of EIF2AK3/PERK exhibits high selectivity over 300 other protein kinases.

This compound prevents endoplasmic reticulum (ER) stress-induced enhancement of PERK and EIF2a phosphorylation, and reduces ATF4 and CAAT/enhancer binding protein homologous protein (CHOP) levels in human and murine cells. (Atkins et al., (2013) Cancer Res. 73(6):1993-2002)
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Featured Articles
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Watch Cells Die with These TUNEL Assay Kits
One established hallmark of apoptosis is DNA fragmentation, commonly measured using the terminal ... more »
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Listen in on Cellular Chatter with These Exosome-Analysis Tools
When it comes to bodily fluids, we tend to think of them as homogeneous. But that isn’t precisely ... more »
 
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Featured Products
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King Fisher Nucleic Acid Purification Systems
Thermo Fisher Scientific Laboratory Equipment (LPG)
Thermo Scientific KingFisher nucleic acid purification products include high speed purification ... more »
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LncPath™ pathway-focused or disease-specific microarrays
Arraystar, Inc
Arraystar’s LncPath™ pathway-focused or disease-specific microarrays are powerful tools to quickly ... more »
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Promotions
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Referral Program | Bigger Discounts
from Rocky Mountain Diagnostics, Inc.
Feeling a budget crunch? Partner up! Bring any other university, institute or department to buy from us, and you both receive 10% off each order, plus you will get free shipping on your order. more »
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Product Reviews
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CD45R/B220 Antibody: Works Out of the Box
Study bone marrow hemopoietic progenitor cells more »
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FLI1/EWSR1 Aquarius FISH Probe from Cytocell
I am using the Cytocell FLI1/EWSR1 probe to assess gain or loss of these target regions in lymphoma ... more »
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Videos
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How to Amplify GC-rich DNA
Amplification of GC-rich DNA targets can be difficult for most traditional DNA polymerases. New England Biolabs has performed tens of thousands of PCR experiments optimizing polymerases so you don’t ... more »
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News
 
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Events
Event details
Immunogenicity
London, United Kingdom
From a clinical perspective, the conference will assess consideration and design of biologic therapeutics, clinical implications and review what the clinical outcomes are from using these immune modulatory approaches. more »
Event details
Biomarkers 2014
Cambridge, UK
SELECTBIO, working with Andreas Jeromin, announces Biomarkers in CNS Drug Discovery and Development: From Discovery to Clinical Diagnostics. This meeting will highlight both current advances in the use of biomarkers in the context of CNS drug discovery and development, and strategies for their ... more »
Event details
Big Data in Pharma
London, United Kingdom
This conference focuses on how to efficiently utilize data and to better identify potential drug candidates and develop more effective medicines. Applying big-data strategies could generate huge value across the healthcare system. Conference includes presentations from leading pharma experts as ... more »
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