Alzheimer’s disease (AD) affects over 5 million Americans, yet no disease-modifying therapy exists. While there is evidence suggesting that abnormal amyloid production and accumulation may play a bigger role in some AD subtypes, the intersection between amyloid buildup, gene expression, and the cellular environment surrounding amyloid-beta (Aβ) plaques remains unclear.
This application note highlights how the Xenium In Situ platform enables high-throughput, spatially resolved gene expression analysis to better understand AD pathogenesis—revealing how amyloid plaques influence local cell types and gene activity at single-cell resolution.