Lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) are both subtypes of non-small cell lung cancer (NSCLC), yet typically present a wide disparity in patient prognosis. Understanding the molecular underpinnings of these different outcomes requires transcriptomic studies at the single cell level.
This application notes shows how the Single Cell Gene Expression Flex, was able to fix and dissociate 32 human lung samples across three clinical stages. Those samples were then multiplexed to profile ~900K individual cells, representing five biological groups, in a single run. The resulting analysis provided innovative insights into the complex biology that drives differential disease progression and patient outcome between two NSCLC subtypes. Download this application note to learn more.