The 3 existing HPV vaccines are capable of preventing the vast majority of cervical cancers. xMAP multiplexing technology, especially the cLIA and total IgG LIA assays, has facilitated the development and clinical testing of these vaccines in a high-throughput and robust manner. These assays have facilitated the simultaneous measurement of type-specific antibodies to several HPV genotypes, and have been collectively used to measure titers in thousands of individuals. Although the vaccines have long since been approved, the multiplex assays are continuing to power studies examining long-term vaccine safety and efficacy, along with the worldwide impact of vaccination against HPV-related diseases.
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