Hematopoietic stem cells (HSCs) are multipotent and self-renewing cells that differentiate into the different lineages of blood cells. They are believed to comprise about 1 in every 10 to 15 thousand bone marrow cells and 1 in 100,000 blood cells. In maintaining the self-renewal and pluripotency of HSCs in culture, specialized media containing key growth factors and signaling molecules are required. Some examples include stem cell factor and thrombopoietin for repopulating mouse HSCs. Consult the supplier pages for details on hematopoietic stem cell media, such as with serum-free formulations or addition of specific factors.