The following heparanase ELISA kits are useful research tools for the measurement of heparanase in biological samples. In humans this protein is encoded by the HPSE gene. This protein is a reported endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. The canonical protein structure is reported to have an amino acid length of 543 residues, a mass of 61.1 kDa, and is a member of the Glycosyl hydrolase 79 protein family. Its subcellular location is known to be in the nucleus, lysosomes, membrane, and is secreted. In addition, it is reported to be highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. As many as 4 protein isoforms have been reported. In certain instances, it is also post-translationally N-glycosylated and cleaved. This protein may also be known as HPA1, HPR1, HPSE1, HSE1, endo-glucoronidase, heparanase-1, and HPA.
Some heparanase ELISA kits can detect targets at levels as low as 15.6 pg/mL and as high as 20 ng/mL. Use the search filters to narrow your search and click on the ELISA kits below for more detailed information, such as reactivity and assay sensitivity.