Anti-TGM1 antibodies are used in the immunodetection of the protein transglutaminase 1. In humans, the canonical protein has a reported length of 817 amino acid residues and a mass of 89.8 kDa. Its subcellular localization is in the membrane. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the tonsil, skin, esophagus, and cervix. A member of the Transglutaminase protein family, TGM1 is known to catalyze the cross-linking of proteins and the conjugation of polyamines to proteins. Post-translational modifications have been described, including palmitoylation, protein cleavage and phosphorylation. The TGM1 gene has been associated with the disease, Ichthyosis. Synonyms for this target antigen include ICR2, KTG, LI, LI1, TGASE, TGK, protein-glutamine gamma-glutamyltransferase K, and ARCI1. TGM1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species.