Anti-SPPL2A antibodies are used in the immunodetection of the protein signal peptide peptidase like 2A. In humans, the canonical protein has a reported length of 520 amino acid residues and a mass of 58.1 kDa. Its subcellular localization is in the lysosomes. It is ubiquitously expressed across many tissue types. It is a member of the Peptidase A22B protein family. Post-translational modifications have been described, including glycosylation. The SPPL2A gene has been associated with the disease, Immunodeficiency. Synonyms for this target antigen include SPP-like 2A, intramembrane cleaving protease, intramembrane protease 3, presenilin-like protein 2, and IMP-3. SPPL2A gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Western Blot is the most common application for the SPPL2A antibodies listed below. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.