Anti-TSEN2 antibodies are used in the immunodetection of the protein tRNA splicing endonuclease subunit 2. In humans, the canonical protein has a reported length of 465 amino acid residues and a mass of 53.2 kDa. Its subcellular localization is in the nucleus. Up to 5 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the cerebellum, vagina, and adrenal gland. A member of the TRNA-intron endonuclease protein family, TSEN2 is known to be involved with mRNA processing. The TSEN2 gene has been associated with the disease, Pontocerebellar hypoplasia. Synonyms for this target antigen include TSEN2 tRNA splicing endonuclease subunit, hsSen2, tRNA-intron endonuclease Sen2, and tRNA-splicing endonuclease subunit Sen2. TSEN2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some TSEN2 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.