Anti-SLC40A1 antibodies are used in the immunodetection of the protein solute carrier family 40 member 1. In humans, the canonical protein has a reported length of 571 amino acid residues and a mass of 62.5 kDa. Its subcellular localization is in the cell membrane. It is notably expressed in erythrocytes. A member of the Ferroportin (FP) (TC 2.A.100) protein family, SLC40A1 is known to be involved with the apoptotic pathway and cellular localization. Post-translational modifications have been described, including ubiquitination and glycosylation.
The SLC40A1 marker can be used to identify Thymic Macrophages and Thymic Cortical Macrophages.* Synonyms for this target antigen include FPN1, HFE4, IREG1, MST079, MSTP079, MTP1, SLC11A3, and FPN. SLC40A1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 230 citations in the literature describe the use of SLC40A1 antibodies in research. Western Blot and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4