Anti-THG-1 antibodies are protein reagents that detect specific antigens. The THG-1 antigen is another term for the human protein tRNA-histidine guanylyltransferase 1 like, encoded by the THG1L gene. The protein is known to function in the response to oxidative stress, among other biological roles. Canonically, it has an amino acid length of 298 residues and a mass of 34.8 kilodaltons. Its subcellular localization is in the mitochondria and cytoplasm and it is reported to be expressed in many tissues. The THG-1 protein is a member of the TRNA(His) guanylyltransferase protein family.