Anti-TESPA1 antibodies are used in the immunodetection of the protein thymocyte expressed, positive selection associated 1. In humans, the canonical protein has a reported length of 521 amino acid residues and a mass of 59.2 kDa. Its subcellular localization is in the ER and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is notably expressed in the caudate and cerebral cortex. TESPA1 is known to be required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Post-translational modifications have been described, including phosphorylation.
The TESPA1 marker can be used to identify Megakaryocytes-Erythroid-Mast Cells Progenitors (MEMP), Deep-Layer Intratelencephalic Neurons, and Gamma-Delta T Cells.* Synonyms for this target antigen include ITPRID3, KIAA0748, protein TESPA1, thymocyte-expressed positive selection-associated protein 1, and HSPC257. TESPA1 gene orthologs have been reported in the mouse, bovine, frog, zebrafish, chimpanzee and chicken species. Immunofluorescence is the most common application for the Tespa1 antibodies listed below. ELISA, Western Blot, and Immunocytochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4