Anti-PROX1 antibodies are used in the immunodetection of the protein prospero homeobox 1. In humans, the canonical protein has a reported length of 737 amino acid residues and a mass of 83.2 kDa. Its subcellular localization is in the nucleus. A member of the Prospero homeodomain protein family, PROX1 is a reported transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. The PROX1 marker can be used to identify Brain Splatter Neurons, Ascending Thin Limb Cells, Medullary Thick Ascending Limb Cells, Lymphatic Endothelial Cells, and Respiratory Lymphatic Vessel Endothelial Cells.* Synonyms for this target antigen include homeobox prospero-like protein PROX1, prospero-related homeobox 1, and prospero homeobox protein 1. PROX1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4