Anti-polymerase (DNA directed), epsilon, catalytic subunit antibodies enable researchers to detect and measure the polymerase (DNA directed), epsilon, catalytic subunit antigen in biological samples. This target is a reported synonym of the POLE gene, which encodes DNA polymerase epsilon, catalytic subunit. This protein is known to function in DNA replication and embryonic organ development, among other biological roles. The human version of polymerase (DNA directed), epsilon, catalytic subunit has a canonical amino acid length of 2286 residues and a protein mass of 261.5 kilodaltons. It is reported to be localized in the nucleus of cells. Other names for this target antigen include CRCS12, FILS, and IMAGEI.