Anti-GRIN2C antibodies are used in the immunodetection of the protein glutamate ionotropic receptor NMDA type subunit 2C. In humans, the canonical protein has a reported length of 1233 amino acid residues and a mass of 134.2 kDa. Its subcellular localization is in the cell membrane. A member of the Glutamate-gated ion channel (TC 1.A.10.1) protein family, GRIN2C is known to be a component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Post-translational modifications have been described, including glycosylation. The GRIN2C marker can be used to identify Gray Matter Chandelier Neurons.* Synonyms for this target antigen include NMDAR2C, NR2C, glutamate receptor ionotropic, NMDA 2C, GluN2C(alt_5'UTR_77nt), GluN2C(alt_5'UTR_87nt), and GluN2C. GRIN2C gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4