Anti-Lanosterol Synthase antibodies are used in the immunodetection of the protein encoded by the LSS gene. In humans, the canonical protein has a reported length of 732 amino acid residues and a mass of 83.3 kDa. Its subcellular localization is in the ER. Alternative splicing is reported to yield 3 different isoforms for this protein. It is widely expressed across many tissue types. A member of the Terpene cyclase/mutase protein family, it is known to be a key enzyme in the cholesterol biosynthesis pathway. Other names for this target antigen include CTRCT44, HYPT14, OSC, 2,3-epoxysqualene-lanosterol cyclase, epididymis secretory sperm binding protein, and APMR4.