Anti-Adenylate Cyclase 8 antibodies are used for the immunodetection of the protein encoded by the ADCY8 gene. In humans, the canonical protein has a reported length of 1251 amino acid residues and a mass of 140.1 kDa. Its subcellular localization is in the cell membrane. It is notably expressed in the brain cortex. A member of the Adenylyl cyclase class-4/guanylyl cyclase protein family, it is known to catalyze the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Other names for this target antigen include ADCY3, HBAC1, adenylate cyclase type 8, ATP pyrophosphate-lyase 8, HEL-S-172mP, and AC8. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of Adenylate Cyclase 8 antibodies have been mentioned in research publications and have associated citations. Immunohistochemistry is a widely used application for these antibodies. ELISA, Western Blot, and Immunofluorescence are also common applications.