Anti-ADRA1A antibodies are used in the immunodetection of the protein adrenoceptor alpha 1A. In humans, the canonical protein has a reported length of 466 amino acid residues and a mass of 51.5 kDa. Its subcellular localization is in the cell membrane, nucleus, and cytoplasm. Up to 9 different isoforms have been reported for this protein. It is found to be expressed in the heart, brain, liver and prostate, but not in the kidney, lung, adrenal, aorta and pituitary. A member of the G-protein coupled receptor 1 protein family, ADRA1A is known to be involved with pathways of aging and the apoptotic pathway.
The ADRA1A marker can be used to identify Deep-Layer Near-Projecting Neurons, Hippocampal Dentate Gyrus Neurons, and Vascular Smooth Muscle Cells.* Synonyms for this target antigen include ADRA1L1, ALPHA1AAR, alpha-1A adrenergic receptor, G protein coupled receptor, alpha-1A adrenoceptor, and ADRA1C. ADRA1A gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 80 citations in the literature describe the use of ADRA1A antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4