Anti-Ameloblastin antibodies are used for the immunodetection of the protein encoded by the AMBN gene. In humans, the canonical protein has a reported length of 447 amino acid residues and a mass of 48.3 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to have ameloblast-specific expression. A member of the Ameloblastin protein family, it is reported to be involved in mineralization and structural organization of enamel. Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Amelogenesis imperfecta 1F. Other names for this target antigen include AI1F and enamel matrix protein. Gene orthologs have been identified in the mouse, rat, bovine, frog and chimpanzee species. Some Ameloblastin antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.