Anti-Heparan Sulfate Proteoglycan 2 antibodies are used for the immunodetection of the protein encoded by the HSPG2 gene. In humans, the canonical protein has a reported length of 4391 amino acid residues and a mass of 468.8 kDa. Its subcellular localization is in the extracellular matrix and is secreted. It is notably expressed in cerebrospinal fluid, fibroblasts and urine. It is reported to be an integral component of basement membranes. Post-translational modifications have been described, including O-glycosylation and protein cleavage. The gene encoding this protein is implicated in Schwartz-Jampel syndrome. Other names for this target antigen include PLC, PRCAN, SJA, SJS, SJS1, and HSPG. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 70 citations in the literature describe the use of Heparan Sulfate Proteoglycan 2 antibodies in research. Immunohistochemistry is a widely used application for these antibodies. ELISA, Western Blot, and Immunofluorescence are also common applications.