Anti-CRPPA antibodies are used in the immunodetection of the protein CDP-L-ribitol pyrophosphorylase A. In humans, the canonical protein has a reported length of 451 amino acid residues and a mass of 49.9 kDa. Its subcellular localization is in the cytoplasm. Up to 2 different isoforms have been reported for this protein. It is widely expressed across many tissue types. A member of the IspD/TarI cytidylyltransferase protein family, CRPPA is known to be involved with axon guidance. The CRPPA gene has been associated with the disease, Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies. Synonyms for this target antigen include 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase homolog, isoprenoid synthase domain containing, and D-ribitol-5-phosphate cytidylyltransferase. CRPPA gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.