Anti-interleukin 36 alpha antibodies are used in the immunodetection of the protein encoded by the IL36A gene. In humans, the canonical protein has a reported length of 158 amino acid residues and a mass of 17.7 kDa. Its subcellular localization is in the cytoplasm and is also secreted. It is reported to be expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. A member of the IL-1 protein family, it is a reported to be a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Other names for this target antigen include FIL1(EPSILON), FIL1E, IL-1F6, IL1(EPSILON), IL1F6, FIL1 epsilon, IL-1 epsilon, and FIL1.