Anti-Myelin Associated Glycoprotein antibodies are used in the immunodetection of the protein encoded by the MAG gene. In humans, the canonical protein has a reported length of 626 amino acid residues and a mass of 69.1 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 3 different isoforms for this protein. A member of the SIGLEC (sialic acid binding Ig-like lectin) protein family, it is reported to be an adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Post-translational modifications have been described, including N-glycosylation, ubiquitination and phosphorylation. Other names for this target antigen include S-MAG, SIGLEC-4A, SIGLEC4A, SPG75, sialic acid binding Ig-like lectin 4A, and GMA.