Anti-CAPN1 antibodies are used in the immunodetection of the protein calpain 1. In humans, the canonical protein has a reported length of 714 amino acid residues and a mass of 81.9 kDa. Its subcellular localization is in the cell membrane and cytoplasm. It is ubiquitously expressed across many tissue types. A member of the Peptidase C2 protein family, CAPN1 is known to be involved with the regulation of cell proliferation and proteolysis. Post-translational modifications have been described, including protein cleavage. The CAPN1 gene has been associated with the disease, Spastic paraplegia. Synonyms for this target antigen include CANP1, CANPL1, SPG76, muCANP, muCL, calpain-1 catalytic subunit, CANP 1, and CANP. CAPN1 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 230 citations in the literature describe the use of Capn1 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.